Evidence map›Paper›PMID 36320246›Full record

ArticleRSC advances2022

A water-soluble membrane transporter for biologically relevant cations.

Kylie Yang, Jessica E Boles, Lisa J White, Kira L F Hilton, Hin Yuk Lai, Yifan Long, Jennifer R Hiscock, Cally J E Haynes

Abstract read
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Rapid Water Permeation by Aramid Foldamer Nanochannels With Hydrophobic Interiors.Angewandte Chemie (International ed. in English) · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kylie YangChemistry Department, UCL 20 Gordon Street London WC1H 0AJ UK cally.haynes@ucl.ac.uk.ORCID https://orcid.org/0000-0002-4455-3681
Jessica E BolesSchool of Chemistry and Forensic Science, University of Kent Canterbury Kent CT2 7NH UK j.r.hiscock@kent.ac.uk.
Lisa J WhiteSchool of Chemistry and Forensic Science, University of Kent Canterbury Kent CT2 7NH UK j.r.hiscock@kent.ac.uk.
Kira L F HiltonSchool of Chemistry and Forensic Science, University of Kent Canterbury Kent CT2 7NH UK j.r.hiscock@kent.ac.uk.
Hin Yuk LaiChemistry Department, UCL 20 Gordon Street London WC1H 0AJ UK cally.haynes@ucl.ac.uk.
Yifan LongChemistry Department, UCL 20 Gordon Street London WC1H 0AJ UK cally.haynes@ucl.ac.uk.
Jennifer R HiscockSchool of Chemistry and Forensic Science, University of Kent Canterbury Kent CT2 7NH UK j.r.hiscock@kent.ac.uk.ORCID https://orcid.org/0000-0002-1406-8802
Cally J E HaynesChemistry Department, UCL 20 Gordon Street London WC1H 0AJ UK cally.haynes@ucl.ac.uk.ORCID https://orcid.org/0000-0003-4262-8560

Funding

Medical Research Council MR/T020415/1
6 · The paper itself

Abstract

Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.

Identifiers

PMID36320246
PMCPMC9520675

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.