Evidence map›Paper›PMID 36320018›Full record

Observational studyFluids and barriers of the CNS2022

Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension.

James L Mitchell, Rebecca Buckham, Hannah Lyons, Jessica K Walker, Andreas Yiangou, Matilde Sassani, Mark Thaller, Olivia Grech, Zerin Alimajstorovic, Marianne Julher and 4 more

Abstract readObservational Study
In one paragraph

Observational study in Fluids and barriers of the CNS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

James L MitchellInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0001-6785-9352
Rebecca BuckhamInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0002-1847-6117
Hannah LyonsInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0003-0105-1064
Jessica K WalkerInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0003-2586-7172
Andreas YiangouInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0001-8905-5734
Matilde SassaniInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0002-0384-7296
Mark ThallerInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0001-7772-2157
Olivia GrechInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0001-5560-802X
Zerin AlimajstorovicInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0001-5622-8301
Marianne JulherDepartment of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.
Georgios TsermoulasInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.
Kristian BrockCancer Research Clinical Trials Unit, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-3921-0166
Susan P MollanInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0002-6314-4437
Alexandra J SinclairInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK. a.b.sinclair@bham.ac.uk.ORCID http://orcid.org/0000-0003-2777-5132

Funding

Medical Research Council MR/K015184/1National Institute for Health Research (NIHR) clinician scientist fellowship NIHR-CS-011-028
6 · The paper itself

Abstract

objectivesIntracranial pressure (ICP) has been thought to vary diurnally. This study evaluates diurnal ICP measurements and quantifies changes in ICP occurring with changes in body posture in active idiopathic intracranial hypertension (IIH).

methodsThis prospective observational study utilized telemetric ICP monitoring in people with active IIH. Participants had the Raumedic p-Tel ICP intraparenchymal device (Raumedic, Hembrechts, Germany) surgically inserted. Changes in ICP in the supine position were evaluated. Then, the ICP was measured in the standing, sitting, supine, left lateral decubitus positions and with coughing and bending. Ultimately, changes in ICP over the course of 24 h were recorded. ISRCTN registration number 12678718.

results15 women were included, mean (standard deviation) age 29.5 (9.5) years, body mass index 38.1 (6.2) kg/m

conclusionThis analysis demonstrated that ICP does not appear to have a diurnal variation in IIH, but varies by position and duration in the supine position. ICP rose at night whilst the patient was continuously supine. Furthermore, brief standing and supine ICP measures in the day predicted daytime prolonged ambulatory measures and end of night peak ICP respectively. This knowledge gives reassurance that ICP can be accurately measured and compared at any time of day in an ambulant IIH patient. These are useful findings to inform clinical measurements and in the interpretation of ICP analyses in IIH.

trial registrationISTCRN (12678718).

Indexed as

Intracranial PressurePseudotumor CerebriAdultFemaleHumansMonitoring, PhysiologicPostureTelemetryDiurnalIdiopathic intracranial hypertensionIntracranial pressurePostureTelemetric monitor

Identifiers

PMID36320018
PMCPMC9628104

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.