ArticleAging clinical and experimental research2023
Centenarians born before 1919 are resistant to COVID-19.
Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians.International journal of molecular sciences · 2026Review
- The long-lived immune system of centenarians.Nature reviews. Immunology · 2026Review
- Centenarian Mortality Rate During COVID-19: Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2025Article
- Mortality Trends in Pre-COVID-19 and COVID-19 Eras Among Oldest Veterans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Mortality causes and health spending by gender and health conditions in octogenarians, nonagenarians and centenarians in Colombia.Scientific reports · 2025Observational
- Sexual dimorphism in immunity and longevity among the oldest old.Frontiers in immunology · 2025Review
- Phylogenetic and epidemiological insights into centenarians' resilience to COVID-19: exploring the role of past coronavirus pandemics.Frontiers in microbiology · 2025Article
- Article
- Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19.Immunity & ageing : I & A · 2024Article
- Sicilian semi- and supercentenarians: identification of age-related T-cell immunophenotype to define longevity trait.Clinical and experimental immunology · 2023Article
- Role of Sex and Age in Fatal Outcomes of COVID-19: Women and Older Centenarians Are More Resilient.International journal of molecular sciences · 2023Review
- An evidence-based debate on epigenetics and immunosenescence in COVID-19.Current research in immunology · 2023Review
- Sex and gender affect immune aging.Frontiers in aging · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although mortality from COVID-19 progressively increases with age, there are controversial data in the literature on the probability of centenarians dying from COVID-19. Moreover, it has been claimed that men in their 90s and 100s are more resilient than women. To gain insight into this matter, we analysed, according to gender, mortality data during the first year of pandemic of Sicilian nonagenarians and centenarians. We used mortality data from the 2019 as a control. The crude excess mortality between the two years was calculated. Data on deaths of Sicilian 90 + years show that, in line with what is known about the different response to infections between the two genders, oldest females are more resilient to COVID-19 than males. Moreover, centenarians born before 1919, but not "younger centenarians", are resilient to COVID-19. This latter datum should be related to the 1918 Spanish flu epidemic, although the mechanisms involved are not clear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.