Evidence map›Paper›PMID 36319934›Full record

ArticleHormones (Athens, Greece)2023

Prevalence and associated risk factors of simple renal cysts in primary hyperparathyroidism.

Davut Sakız, Muhammed Erkam Sencar, Murat Çalapkulu, İlknur Öztürk Ünsal, Muhammed Kızılgül, Bekir Uçan, Mustafa Özbek, Erman Çakal

Abstract read
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In one paragraph

Article in Hormones (Athens, Greece), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Genotype-Phenotype Correlations in the Hyperparathyroidism-Jaw Tumor Syndrome.The Journal of clinical endocrinology and metabolism · 2025
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Davut SakızDepartment of Endocrinology and Metabolism, Mardin Training and Research Hospital, 47100, Mardin, Turkey. davut.dr@hotmail.com.ORCID http://orcid.org/0000-0003-1480-888X
Muhammed Erkam SencarMedicana International Ankara Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0001-5581-4886
Murat ÇalapkuluDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0002-7445-2275
İlknur Öztürk ÜnsalDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0003-3999-6426
Muhammed KızılgülDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0002-8468-9196
Bekir UçanDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0002-0810-5224
Mustafa ÖzbekDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0003-1125-3823
Erman ÇakalDepartment of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0003-4455-7276
Sağlık Bilimleri Üniversitesi · TRMardin Artuklu University · TRMemorial Ankara Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious studies have pointed to the role of parathormone (PTH) in the development of simple renal cysts. However, there is insufficient evidence related to simple renal cysts in primary hyperparathyroidism (PHPT). Therefore, this study aimed to evaluate the prevalence and risk factors associated with renal cysts in PHPT patients.

methodsIn this retrospective study, we included 235 patients treated surgically for PHPT and 147 control subjects. The clinical and physical examination findings, laboratory test results, and neck and urinary system ultrasonography examination findings were evaluated. Postoperative parathyroid adenoma volume and weight were also recorded.

resultsSimple renal cysts were found in 53 PHPT patients (22.6%) and in 15 control subjects (10.2%) (p = 0.002). Kidney stones were found in 33 PHPT patients (14%) and in only seven control subjects (4.8%) (p = 0.004). The presence of PHPT and high PTH levels independently supported the development of a simple renal cyst. Advanced age was determined as a risk factor for the development of simple renal cysts, and the presence of kidney stones was an independent predictor of simple renal cysts in PHPT patients. There was no relationship between the presence of simple renal cysts and the volume and weight of parathyroid adenoma.

conclusionA diagnosis of PHPT, high PTH levels, advanced age, and kidney stones are independent risk factors for simple renal cysts in PHPT patients. These patients should be evaluated regularly for complications of renal cysts and nephrolithiasis.

Indexed as

Hyperparathyroidism, PrimaryKidney CalculiKidney Diseases, CysticParathyroid NeoplasmsCalciumHumansParathyroid HormonePrevalenceRetrospective StudiesRisk FactorsCalciumParathyroid HormoneHypercalcemiaKidney stoneNephrolithiasisParathyroid hormone

Identifiers

PMID36319934
OpenAlexW4307969021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.