Evidence map›Paper›PMID 36319836›Full record

ArticleScientific reports2022

Immune mobilising T cell receptors redirect polyclonal CD8

Zoë Wallace, Jakub Kopycinski, Hongbing Yang, Michelle L McCully, Christian Eggeling, Jakub Chojnacki, Lucy Dorrell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Zoë WallaceNuffield Department of Medicine, University of Oxford, Oxford, UK. zoe.wallace@immunocore.com.
Jakub KopycinskiNuffield Department of Medicine, University of Oxford, Oxford, UK.
Hongbing YangNuffield Department of Medicine, University of Oxford, Oxford, UK.
Michelle L McCullyImmunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, UK.
Christian EggelingMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Jakub ChojnackiMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Lucy DorrellNuffield Department of Medicine, University of Oxford, Oxford, UK.
University of Oxford · GBImmunocore (United Kingdom) · GBMRC Human Immunology Unit · GBOxford BioMedica (United Kingdom) · GB

Funding

Medical Research Council G0902418Medical Research Council MC_UU_00008/9Medical Research Council MC_UU_12010/Medical Research Council MC_UU_12010/9Medical Research Council MC_UU_12025Medical Research Council MR/K01577X/1Wellcome Trust 104924/14/Z/14
6 · The paper itself

Abstract

T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8

Indexed as

HIV-1HIV InfectionsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansImmunological SynapsesReceptors, Antigen, T-CellReceptors, Antigen, T-Cell

Identifiers

PMID36319836
PMCPMC9626491
OpenAlexW4308028084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.