Evidence map›Paper›PMID 36319818›Full record

ArticleCellular oncology (Dordrecht, Netherlands)2023

CoQ

Javier Frontiñán-Rubio, Emilio Llanos-González, Sonia García-Carpintero, Juan Ramón Peinado, Inmaculada Ballesteros-Yáñez, Margarita Villar Rayo, José de la Fuente, Víctor M Pérez-García, Luis A Perez-Romasanta, Marcos Malumbres and 2 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Cellular oncology (Dordrecht, Netherlands), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Coenzyme Q10 and Intracellular Signalling Pathways: Clinical Relevance.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. New Insights on the Uptake and Trafficking of Coenzyme Q.Antioxidants (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Javier Frontiñán-RubioDepartment of Medical Sciences, Faculty of Medicine, University of Castilla-La Mancha, 13071, Ciudad Real, Spain.
Emilio Llanos-GonzálezDepartment of Medical Sciences, Faculty of Medicine, University of Castilla-La Mancha, 13071, Ciudad Real, Spain.
Sonia García-CarpinteroDepartment of Medical Sciences, Faculty of Medicine, University of Castilla-La Mancha, 13071, Ciudad Real, Spain.
Juan Ramón PeinadoDepartment of Medical Sciences, Faculty of Medicine, University of Castilla-La Mancha, 13071, Ciudad Real, Spain.
Inmaculada Ballesteros-YáñezEMAS Group, Faculty of Medicine, Regional Centre for Biomedical Research, University of Castilla-La Mancha, Ciudad Real, Spain.
Margarita Villar RayoSaBio Research Group, Hunting Resources Research Institute (IREC), Ciudad Real, Spain.
José de la FuenteSaBio Research Group, Hunting Resources Research Institute (IREC), Ciudad Real, Spain.
Víctor M Pérez-GarcíaLaboratory of Mathematical Oncology, University of Castilla-La Mancha, Ciudad Real, Spain.
Luis A Perez-RomasantaRadiology and Medicinal Physics, Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Marcos MalumbresCell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Francisco J AlcaínDepartment of Medical Sciences, Faculty of Medicine, University of Castilla-La Mancha, 13071, Ciudad Real, Spain. franciscoj.alcain@uclm.es.
Mario Durán-PradoDepartment of Medical Sciences, Faculty of Medicine, University of Castilla-La Mancha, 13071, Ciudad Real, Spain. mario.duran@uclm.es.
University of Castilla-La Mancha · ESInstituto de Investigación en Recursos Cinegéticos · ESInstituto de Investigación Biomédica de Salamanca · ESSpanish National Cancer Research Centre · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMost monotherapies available against glioblastoma multiforme (GBM) target individual hallmarks of this aggressive brain tumor with minimal success. In this article, we propose a therapeutic strategy using coenzyme Q

methodsXenografts of U251 cells in nu/nu mice were used to assay tumor growth, hypoxia, angiogenesis, and inflammation. An orthotopic model was used to explore microglial infiltration, tumor growth, and invasion into the brain parenchyma. Cell proliferation, migration, invasion, proteome remodeling, and secretome were assayed in vitro. Conditioned media were used to assay angiogenesis, monocyte chemoattraction, and differentiation into macrophages in vitro.

resultsCoQ

conclusionsCoQ

Indexed as

Brain NeoplasmsGlioblastomaAnimalsAntioxidantsCell Line, TumorHumansHypoxiaInflammationMiceProteomeUbiquinoneAntioxidantsProteomeUbiquinoneAngiogenesisCoenzyme Q10GlioblastomaInflammationInvasion

Identifiers

PMID36319818
PMCPMC9947058
OpenAlexW4307829806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.