SynthesisScientific reports2022
Prevalence and characteristics of dry eye disease in Parkinson's disease: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Impact of coronavirus disease 2019 pandemic on the trends of care-seeking behavior for ocular diseases: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Beyond motor recovery: subthalamic nucleus deep brain stimulation may improve blinking and dry eye symptoms without restoring tear film homeostasis in Parkinson's disease.BMC ophthalmology · 2026Observational
- Detection of α-synuclein seeding activity in tear fluid as a candidate biomarker for Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives-A Narrative Review.Movement disorders clinical practice · 2026Review
- Corneal epithelial thickness can reflect the stage of Parkinson's disease and the severity of dry eye.Frontiers in aging neuroscience · 2026Article
- A Comprehensive Analysis of Meibomian Gland Function, Corneal Sensitivity, and Tear Parameters in Early-Stage Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Dry Eye Disease and Psychiatric Disorders: Neuroimmune Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2025Review
- Ocular Surface Changes Associated with Neurological Diseases.Medicina (Kaunas, Lithuania) · 2025Review
- Conjunctival impression cytology and tear film analysis in early-stage Parkinson's disease.European journal of ophthalmology · 2025Article
- Retinal Neurovascular Signatures in Parkinson's Disease.Investigative ophthalmology & visual science · 2025Article
- Cognitive Effect of Levetiracetam in Patients with Alzheimer's Disease or Mild Cognitive Impairment: A Systematic Review.Current therapeutic research, clinical and experimental · 2025Review
- Evaluation of conjunctival flora in congenital ptosis.International journal of ophthalmology · 2025Article
- Relationship between dry eye disease and myopia: A systematic review and meta-analysis.Heliyon · 2024Article
- Video-based analysis of the blink reflex in Parkinson's disease patients.Biomedical engineering online · 2024Article
- Visual Dysfunction in Parkinson's Disease.Brain sciences · 2023Review
- Honey-Related Treatment Strategies in Dry Eye Disease.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Narrative Review Concerning the Clinical Spectrum of Ophthalmological Impairments in Parkinson's Disease.Neurology international · 2023Review
- Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review.Life (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 3 institutions in 1 country.
Funding
Abstract
We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson's disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian-Laird random-effects model. Prevalence of subjective DED symptoms in patients with PD and mean differences in blink rate, corneal thickness, tear film breakup time, and tear secretion volume on Schirmer test I were compared to those in controls. Of 383 studies, 13 (1519 patients with PD) and 12 were included in qualitative and quantitative syntheses, respectively. Meta-analysis revealed a 61.1% prevalence of subjective DED symptoms in PD and that, compared with controls, patients with PD had significantly lower blink rate, thinner corneal thickness, shorter tear film breakup time, and lower tear secretion volumes on Schirmer test I, without and with anesthesia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.