ArticleScientific reports2022
BMI variability and incident diabetes mellitus, Tehran Lipid and Glucose Study (TLGS).
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Cardiovascular Disease Mortality Events and Predictors in the Tehran Lipid and Glucose Study: A 20-Year Cohort Review .International journal of endocrinology and metabolism · 2026Review
- Association Between Sleep Disorders and Adverse Cardiovascular Outcomes in Patients with Chronic Obstructive Pulmonary Disease: Insights from the UK Biobank.International journal of chronic obstructive pulmonary disease · 2026Article
- Assessing the Impact of BMI and Glycaemic Control on Cardiac Autonomic Neuropathy in Patients with Early and Long-standing Diabetes Mellitus: A Window of Opportunity.Annals of neurosciences · 2025Review
- Review
- Relationship between the triglyceride glucose index and time in range: A cross-sectional study based on patients with type 2 diabetes mellitus.The Journal of international medical research · 2025Article
- Association between body mass index trajectories and type 2 diabetes incidence over an 18-year follow-up in the Tehran Lipid and Glucose Study.Scientific reports · 2024Article
- The association of body mass index variability with cardiovascular disease and mortality: a mediation analysis of pooled cohorts.Frontiers in endocrinology · 2024Article
- Lifestyle and Quality of Life of Women with Diagnosed Hypothyroidism in the Context of Metabolic Disorders.Metabolites · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous epidemiologic studies debated the association of body mass index (BMI) trends with cardiovascular disease and mortality. This study aimed to evaluate the association of BMI variability and slope with the incidence of Type 2 diabetes mellitus (T2DM) in a sex-stratified 15.8-year follow-up in the population-based Tehran Lipid and Glucose Study (TLGS). Of 10,911 individuals aged 20-60 years, 4981 subjects were included and followed for 15.8-years. The slope coefficient of BMI in the linear regression model represented individuals' BMI trends up to the incidence of DM. The root mean squared error (RMSE) of the BMI linear trend was selected to reflect BMI variability through six follow-ups. Cox proportional hazards regression was used to investigate the association of the baseline BMI, BMI slope and RMSE with the incidence of T2DM among men and women. Multivariable-adjusted HRs of T2DM for each SD increment in BMI slope was 1.18 (95% CI: 0.94-1.48, p = 0.161) in normal weight men and 1.26 (95% CI: 1.10-1.44, p = 0.001) in overweight and obese men. However, in women, each SD increment in BMI slope increased the risk of T2DM with a HR of 1.19 (95% CI: 1.01-1.40, p = 0.039) in normal weight, and 1.14 (95% CI: 1.08-1.19, p < 0.001) in women with BMI ≥ 25 kg/m
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