Evidence map›Paper›PMID 36319108›Full record

Observational studyNeurology2023

Association of Regional Atrophy With Naming Decline in Primary Progressive Aphasia.

Bonnie L Breining, Andreia Vasconcellos Faria, Donna Clark Tippett, Melissa Dawn Stockbridge, Erin L Meier, Brian Caffo, Olivia Hermann, Rhonda Friedman, Aaron Meyer, Kyrana Tsapkini and 1 more

Open access · hybridAbstract readObservational Study

PubMed Full text at PMC Publisher

In one paragraph

Observational study in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

2.1field-weighted citation impact, top 13% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

Brain patterns and risk factors in the FINGER RCT multimodal lifestyle intervention.The journal of prevention of Alzheimer's disease · 2025
Trial
Verbal learning in logopenic variant Primary Progressive Aphasia: An EEG investigation.Neurobiology of aging · 2026
Article
Linking silent pause locations in speech to amyloid and tau deposition in cognitively unimpaired individuals.Journal of Alzheimer's disease : JAD · 2025
Article
Lesion and lesion network localization of dysnomia after epilepsy surgery.Brain : a journal of neurology · 2025
Article
Brain injury, endocrine disruption, and immune dysregulation in HIV-positive men who have sex with men with late HIV diagnosis.Frontiers in immunology · 2025
Article
Primary Progressive Aphasia Treatment: Current Treatment Options in Neurology Article Topic: Management of Primary Progressive Aphasia.Current treatment options in neurology · 2025
Review
Anomia: Deciphering Functional Neuroanatomy in Primary Progressive Aphasia Variants.Brain sciences · 2023
Article
Verb Frequency and Density Drive Naming Performance in Primary Progressive Aphasia.Aphasiology · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Bonnie L BreiningFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC.ORCID 0000-0001-7197-6164

Andreia Vasconcellos FariaFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC.ORCID 0000-0002-1673-002X

Donna Clark TippettFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC.ORCID 0000-0001-9485-9745

Melissa Dawn StockbridgeFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC.

Erin L MeierFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC.ORCID 0000-0002-5750-597X

Brian CaffoFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC.ORCID 0000-0002-0793-9497

Olivia HermannFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC.

Rhonda FriedmanFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC.ORCID 0000-0001-6366-5251

Aaron MeyerFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC.

Kyrana TsapkiniFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC.ORCID 0000-0001-6020-5532

Argye Elizabeth HillisFrom the Johns Hopkins University School of Medicine (B.L.B., A.V.F., D.C.T., M.D.S., E.L.M., O.H., K.T., A.E.H.), Baltimore, MD; Johns Hopkins University (B.C.), Bloomberg School of Public Health, Baltimore, MD; and Georgetown University (R.F., A.M.), Washington, DC. argye@jhmi.edu.

Johns Hopkins University · US

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2016 to 2025

$25.0M

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026

$9.9M

Rehabilitation and Prophylaxis of Anomia in Primary Progressive AphasiaR01DC011317 · NIDCD · GEORGETOWN UNIVERSITY · PI FRIEDMAN, RHONDA B, MEYER, AARON M · 2011 to 2021

$6.4M

Statistical methods for structural and functional integration in multi-modal neuroimaging dataR01EB029977 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI CAFFO, BRIAN SCOTT · 2021 to 2024

$1.9M

NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB029977NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC011317

6 · The paper itself

Abstract

BACKGROUND AND

objectivesPrimary progressive aphasia (PPA) is a neurodegenerative condition that predominantly impairs language. Most investigations of how focal atrophy affects language consider 1 time point compared with healthy controls. However, true atrophy quantification requires comparing individual brains over time. In this observational cohort study, we identified areas where focal atrophy was associated with contemporaneous decline in naming in the same individuals.

methodsCross-sectional analyses-related Boston Naming Test (BNT) performance and volume in 22 regions of interests (ROIs) at each time point using Least Absolute Shrinkage and Selection Operator (LASSO) regression. Longitudinal analysis evaluated changes in BNT performance and change in volume in the same ROIs.

resultsParticipants (N = 62; 50% female; mean age = 66.8 ± 7.4 years) with PPA completed the BNT and MRI twice (mean = 343.9 ± 209.0 days apart). In cross-sectional left inferior frontal gyrus pars opercularis, superior temporal pole, middle temporal gyrus, and inferior temporal gyrus were identified as critical for naming at all time points. Longitudinal analysis revealed that increasing atrophy in the left supramarginal gyrus and middle temporal pole predicted greater naming decline, as did female sex and longer intervals between time points. DISCUSSION: Although cross-sectional analyses identified classic language areas that were consistently related to poor performance at multiple time points, it was not increasing atrophy in these areas that lead to further decline: longitudinal analysis of each person's atrophy over time instead identified nearby but distinct regions where increased atrophy was related to decreasing performance. The results demonstrate that directly examining atrophy (in each individual) over time furthers understanding of decline in PPA and reveal the importance of left supramarginal gyrus and middle temporal pole in maintaining naming when areas normally critical for language degenerate. The novel results provide insight into how the underlying disease progresses to result in the clinical decline in naming, the deficit most common among all 3 PPA variants.

Indexed as

Aphasia, Primary ProgressiveAgedAtrophyBrainCross-Sectional StudiesFemaleHumansLanguageMagnetic Resonance ImagingMaleMiddle Aged

Identifiers

PMID36319108

DOI10.1212/WNL.0000000000201491

PMCPMC9946192

OpenAlexW4307975983

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.