Evidence map›Paper›PMID 36319086›Full record

ArticleJournal of neurointerventional surgery2023

Endovascular transmural access to carotid artery perivascular tissues: safety assessment of a novel technique.

Wi Jin Kim, Hasitha Milan Samarage, David Zarrin, Keshav Goel, Anthony C Wang, Jeremiah Johnson, Kambiz Nael, Geoffrey P Colby

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurointerventional surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wi Jin KimDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0002-0073-5408
Hasitha Milan SamarageDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
David ZarrinDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0001-8666-4972
Keshav GoelDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Anthony C WangDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
Jeremiah JohnsonDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
Kambiz NaelDepartment of Radiological Sciences, University of California Los Angeles, Los Angeles, California, USA.
Geoffrey P ColbyDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA gcolby@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA Neurosurgery Research Training and Education ProgramR25NS079198 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIAU, LINDA M · 2012 to 2021
$1.2M
NINDS NIH HHS R25 NS079198
6 · The paper itself

Abstract

backgroundRecent advances in endovascular devices have allowed access and targeting of perivascular tissues of the peripheral circulation. The perivascular tissues of the cervical and cranial circulations have many important structures of clinical significance, yet the feasibility and safety of such an approach has not been demonstrated.

objectiveTo evaluate the safety of a novel endovascular transmural approach to target the perivascular tissues of the common carotid artery in swine.

methodsA micro-infusion device was positioned in the carotid arteries of three Yorkshire pigs (six carotid arteries in total), and each carotid artery was punctured 10 times in the same location to gain access to the perivascular tissues. Digital subtraction angiography was used to evaluate vessel injury or contrast extravasation. MRI and MR angiography were used to evaluate evidence of cerebral ischemia or vessel injury. Post-mortem tissue analysis was performed to assess the level of extravascular hematoma and intravascular dissection.

resultsNone of the tested carotid arteries showed evidence of vessel injury (dissection or perforation) or intravascular thrombosis. MRI performed after repeated puncture was negative for neck hematoma and brain ischemia. Post-mortem tissue analysis of the carotid arteries showed mild adventitial staining with blood, but without associated hematoma and without vessel dissection.

conclusionRepeated puncture of the carotid artery to gain access to the perivascular tissues using a novel endovascular transmural approach is safe in a swine model. This represents a novel approach to various tissues in close proximity to the cervical and cranial vasculature.

Indexed as

Brain IschemiaEndovascular ProceduresAngiography, Digital SubtractionAnimalsCarotid ArteriesCarotid Artery, CommonHematomaSwineCervicalDeviceNeckTechniqueVessel Wall

Identifiers

PMID36319086
PMCPMC10149561
OpenAlexW4307976050

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.