Evidence map›Paper›PMID 36318983›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder.

Zenas C Chao, Daniel G Dillon, Yi-Hung Liu, Elyssa M Barrick, Chien-Te Wu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. [Research on weighted hypergraph attention neural network for the diagnosis of psychiatric disorders using brain functional connectivity networks].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Zenas C ChaoFrom the International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan (Chao, Wu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass. (Dillon, Barrick); Harvard Medical School, Boston, Mass. (Dillon); the Department of Mechanical Engineering, National Taiwan University of Science and Technology, Taiwan (Liu); the Yuan-Rung Medical System, Changhua, Taiwan (Liu) zenas.c.chao@gmail.com chientevincewu@gmail.com.
Daniel G DillonFrom the International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan (Chao, Wu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass. (Dillon, Barrick); Harvard Medical School, Boston, Mass. (Dillon); the Department of Mechanical Engineering, National Taiwan University of Science and Technology, Taiwan (Liu); the Yuan-Rung Medical System, Changhua, Taiwan (Liu).
Yi-Hung LiuFrom the International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan (Chao, Wu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass. (Dillon, Barrick); Harvard Medical School, Boston, Mass. (Dillon); the Department of Mechanical Engineering, National Taiwan University of Science and Technology, Taiwan (Liu); the Yuan-Rung Medical System, Changhua, Taiwan (Liu).
Elyssa M BarrickFrom the International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan (Chao, Wu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass. (Dillon, Barrick); Harvard Medical School, Boston, Mass. (Dillon); the Department of Mechanical Engineering, National Taiwan University of Science and Technology, Taiwan (Liu); the Yuan-Rung Medical System, Changhua, Taiwan (Liu).
Chien-Te WuFrom the International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan (Chao, Wu); the Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Mass. (Dillon, Barrick); Harvard Medical School, Boston, Mass. (Dillon); the Department of Mechanical Engineering, National Taiwan University of Science and Technology, Taiwan (Liu); the Yuan-Rung Medical System, Changhua, Taiwan (Liu) zenas.c.chao@gmail.com chientevincewu@gmail.com.
Harvard University · USChanghua Christian Hospital · TWNational Taiwan University of Science and Technology · TW

Funding

Computational mechanisms of memory disruption in depressionR01MH111676 · NIMH · MCLEAN HOSPITAL · PI DILLON, DANIEL G · 2019 to 2023
$2.0M
Neuroscience of Reward-Related Learning and Memory in DepressionR00MH094438 · NIMH · MCLEAN HOSPITAL · PI DILLON, DANIEL G · 2014 to 2016
$740k
NIMH NIH HHS R00 MH094438NIMH NIH HHS R01 MH111676
6 · The paper itself

Abstract

backgroundA hyperactive default mode network (DMN) has been observed in people with major depressive disorder (MDD), and weak DMN suppression has been linked to depressive symptoms. However, whether dysregulation of the DMN contributes to blunted positive emotional experience in people with MDD is unclear.

methodsWe recorded 128-channel electroencephalograms (EEGs) from 24 participants with MDD and 31 healthy controls in a resting state (RS) and an emotion-induction state (ES), in which participants engaged with emotionally positive pictures. We combined Granger causality analysis and data-driven decomposition to extract latent brain networks shared among states and groups, and we further evaluated their interactions across individuals.

resultsWe extracted 2 subnetworks. Subnetwork 1 represented a delta (δ)-band (1~4 Hz) frontal network that was activated more in the ES than the RS (i.e., task-positive). Subnetwork 2 represented an alpha (α)-band (8~13 Hz) parietal network that was suppressed more in the ES than the RS (i.e., task-negative). These subnetworks were anticorrelated in both the healthy control and MDD groups, but with different sensitivities: for participants with MDD to achieve the same level of task-positive (subnetwork 1) activation as healthy controls, more suppression of task-negative (subnetwork 2) activation was necessary. Furthermore, the anticorrelation strength in participants with MDD correlated with the severity of 2 core MDD symptoms: anhedonia and rumination. LIMITATIONS: The sample size was small.

conclusionOur findings revealed altered coordination between 2 functional networks in MDD and suggest that weak suppression of the task-negative α-band parietal network contributes to blunted positive emotional responses in adults with depression. The subnetworks identified here could be used for diagnosis or targeted for treatment in the future.

Indexed as

Major Depressive DisorderAdultAnhedoniaBrain MappingHumansMagnetic Resonance ImagingNeural Pathways

Identifiers

PMID36318983
PMCPMC9633055
OpenAlexW4308016661

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.