Evidence map›Paper›PMID 36318757›Full record

ArticleACS applied materials & interfaces2022

Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers.

Niranjan Meher, Gary W Ashley, Anil P Bidkar, Suchi Dhrona, Cyril Fong, Shaun D Fontaine, Denis R Beckford Vera, David M Wilson, Youngho Seo, Daniel V Santi and 2 more

Open access · hybridAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  6. State-of-the-art application of nanoparticles in radiotherapy: a platform for synergistic effects in cancer treatment.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
  7. Article
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  13. "Biomaterials translational · 2024
    Review
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  15. Article
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  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Niranjan MeherDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, United States.ORCID 0000-0003-3558-3712
Gary W AshleyProLynx Inc., San Francisco, California 94158, United States.
Anil P BidkarDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, United States.ORCID 0000-0003-1249-1081
Suchi DhronaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, United States.
Cyril FongDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, United States.
Shaun D FontaineProLynx Inc., San Francisco, California 94158, United States.
Denis R Beckford VeraDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, United States.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, United States.ORCID 0000-0002-1095-046X
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, United States.
Daniel V SantiProLynx Inc., San Francisco, California 94158, United States.
Henry F VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, United States.ORCID 0000-0003-2849-0841
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, United States.ORCID 0000-0002-8694-1199
University of California, San Francisco · USProLynx (United States) · US

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7M
Molecular imaging of novel PARP inhibitor nanomedicine deliveryR01CA266666 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGGARWAL, RAHUL, FLAVELL, ROBERT RICHARD · 2022 to 2025
$2.4M
NCI NIH HHS P30 CA082103NCI NIH HHS R01 CA266666
6 · The paper itself

Abstract

Tumoral uptake of large-size nanoparticles is mediated by the enhanced permeability and retention (EPR) effect, with variable accumulation and heterogenous tumor tissue penetration depending on the tumor phenotype. The performance of nanocarriers

Indexed as

Antigens, SurfacePolymersProstatic NeoplasmsCell Line, TumorGlutamate Carboxypeptidase IIGlutaratesHumansLigandsMaleProstateAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IIGlutaratesLigandsPolymers(S)-2-(3-((S)-5-amino-1-carboxypentyl)ureido)-pentanedioic aciddeep tumor penetrationenhanced permeability and retention (EPR) effectpolymer nanocarrierspositron emission tomography (PET) imagingprostate-specific membrane antigen (PSMA)

Identifiers

PMID36318757
PMCPMC9673064
OpenAlexW4307975410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.