Evidence map›Paper›PMID 36318723›Full record

ArticleInternational journal of radiation biology2023

Radiation and CNS effects: summary of evidence from a recent symposium of the Radiation Research Society.

Lydia B Zablotska, Ljubica Zupunski, Klervi Leuraud, Julie Lopes, Joshua Hinkle, Tyler Pugeda, Thomas Delgado, John Olschowka, Jacqueline Williams, M Kerry O'Banion and 6 more

Abstract read
In one paragraph

Article in International journal of radiation biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lydia B ZablotskaDepartment of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0778-1108
Ljubica ZupunskiEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0002-2144-4247
Klervi LeuraudLaboratory of Epidemiology (LEPID), Institute for Radiological Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, France.ORCID 0000-0001-5492-168X
Julie LopesLaboratory of Epidemiology (LEPID), Institute for Radiological Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, France.ORCID 0000-0003-2903-4127
Joshua HinkleDepartment of Neuroscience, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.ORCID 0000-0003-2942-8855
Tyler PugedaDepartment of Neuroscience, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.ORCID 0000-0002-7159-2811
Thomas DelgadoDepartment of Neuroscience, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.ORCID 0000-0002-8746-307X
John OlschowkaDepartment of Neuroscience, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.ORCID 0000-0002-8478-7773
Jacqueline WilliamsDepartment of Environmental Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.ORCID 0000-0002-5635-1526
M Kerry O'BanionDepartment of Neuroscience, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA.ORCID 0000-0003-1246-3363
John D BoiceNational Council on Radiation Protection and Measurements, Bethesda, MD, USA.ORCID 0000-0002-8755-1299
Sarah S CohenVanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-0421-1983
Michael T MummaVanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-7506-8710
Lawrence T DauerMemorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-5629-8462
Richard A BrittenDepartment of Radiation Oncology, Eastern Virginia Medical School, Norfolk, VA, USA.ORCID 0000-0002-6919-5753
Samuel StephensonSchool of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA.ORCID 0000-0003-2478-9563

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748World Health Organization 001
6 · The paper itself

Abstract

This article summarizes a Symposium on 'Radiation risks of the central nervous system' held virtually at the 67th Annual Meeting of the Radiation Research Society, 3-6 October 2021. Repeated low-dose radiation exposure over a certain period could lead to reduced neuronal proliferation, altered neurogenesis, neuroinflammation and various neurological complications, including psychological consequences, necessitating further research in these areas. Four speakers from radiation biology, genetics and epidemiology presented the latest data from their studies seeking insights into this important topic. This symposium highlighted new and important directions for further research on mental health disorders, neurodegenerative conditions and cognitive impairment. Future studies will examine risks of mental and behavioral disorders and neurodegenerative diseases following protracted radiation exposures to better understand risks of occupational exposures as well as provide insights into risks from exposures to galactic cosmic rays.

Indexed as

Cosmic RadiationOccupational ExposureRadiation ExposureCentral Nervous SystemCNS effectsdementianeurodegenerative diseasesParkinson’s diseaseradiationradiation risks

Identifiers

PMID36318723
PMCPMC10759179

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.