Evidence map›Paper›PMID 36318612›Full record

ArticleJournal of medicinal chemistry2022

Structure-Activity Relationship Study of

Hyunjung Kim, Di Bai, Sadashib Ghosh, Michael L Franks, Xifeng Wang, Cheng Yan, Zheng Liu, Ping Zhang, Suzanne M Michalek, Jianmei W Leavenworth and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Development of semisynthetic saponin immunostimulants.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Hyunjung KimDepartment of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
Di BaiDepartment of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
Sadashib GhoshDepartment of Neurosurgery, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
Michael L FranksDepartment of Neurosurgery, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
Xifeng WangDepartment of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
Cheng YanDepartment of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
Zheng LiuDepartment of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China.
Ping ZhangDepartment of Pediatric Dentistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
Suzanne M MichalekDepartment of Microbiology, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
Jianmei W LeavenworthDepartment of Neurosurgery, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.
Pengfei WangDepartment of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama 35294, United States.ORCID 0000-0002-0285-2069
University of Alabama at Birmingham · USCentral China Normal University · CN

Funding

Contribution of the effector Treg-B-antibody nexus to the regulation of CNS autoimmunityR01AI148711 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEAVENWORTH, JIANMEI WU · 2020 to 2024
$2.2M
Development of Structurally Defined Synthetic Vaccine Adjuvants-equip supR01GM120159 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, PENGFEI · 2017 to 2020
$1.2M
NIAID NIH HHS R01 AI148711NIGMS NIH HHS R01 GM120159
6 · The paper itself

Abstract

VSA-2 is a recently developed semisynthetic saponin immunostimulant. It is prepared by incorporating a terminal-functionalized side chain to the branched trisaccharide domain at the C3 position of

Indexed as

MomordicaSaponinsAdjuvants, ImmunologicAdjuvants, VaccineSaposinsStructure-Activity RelationshipAdjuvants, ImmunologicAdjuvants, VaccineMomordica saponin IISaponinsSaposinsVSA-2

Identifiers

PMID36318612
PMCPMC10202417
OpenAlexW4307841907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.