SynthesisJournal of global health2022
Adverse childhood experiences and risk of diabetes: A systematic review and meta-analysis.
Synthesis in Journal of global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Association of Adverse Childhood Experiences and Metabolic Syndrome: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Metabolic markers in bipolar disorder with childhood trauma exposure: a systematic review.CNS spectrums · 2026Pooled it
- Global landscape, research hotspots, and evolutionary trends in childhood adversity and chronic disease research: a bibliometric analysis based on three databases.Frontiers in public health · 2026Pooled it
- Early Life Stress and Adversity in Children: Neuroendocrine Mechanisms, Epigenetic Regulation, and Lifespan Developmental Outcomes-A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Childhood adversity and trajectories of health and quality of life in Australian children and adolescents: a latent class analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Unseen wounds of childhood: Emotional abuse, neglect, and later diabetes vulnerability in Saudi Arabia: A Cross-sectional study.Medicine · 2026Article
- Patterns of violence exposure in a life-course perspective and associations to mental and physical health problems and health-related risk behaviors among women and men in Sweden: A latent class analysis.SSM - population health · 2025Article
- Lifetime Exposure to Violence and Early Cardiometabolic Risk Factors in a Healthy Swedish Cohort.Journal of the American Heart Association · 2025Article
- Violence in adulthood amplifies the health correlates of childhood maltreatment.BMC public health · 2025Article
- Association of Early-life Trauma With Gestational Diabetes and Hypertensive Disorders of Pregnancy.Epidemiology (Cambridge, Mass.) · 2025Article
- Classification and identification of risk factors for type 2 diabetes.World journal of diabetes · 2025Review
- Association of childhood health with adulthood chronic kidney disease: results from the China Health and Retirement Longitudinal Study.Frontiers in public health · 2025Article
- Stressful events throughout the life cycle and social inequalities in a cohort study.Cadernos de saude publica · 2025Article
- Specific effects of distinct types of adverse childhood experiences on the co-occurrence of non-suicidal self-injury and suicidal behaviors among Chinese adolescents: a latent class analysis.Frontiers in psychiatry · 2025Article
- Relationships between childhood adversity and inflammatory biomarkers in adulthood: A cross-sectional analysis of a middle-to older-aged population.SSM - population health · 2024Article
- Childhood maltreatment and risk of endocrine diseases: an exploration of mediating pathways using sequential mediation analysis.BMC medicine · 2024Article
- Role of stress and early-life stress in the pathogeny of inflammatory bowel disease.Frontiers in neuroscience · 2024Review
- Prevalence, subtypes, and risk factors of adverse childhood experiences among Chinese residents: a multicenter cross-sectional study.Frontiers in public health · 2024Article
- Child Maltreatment and Metabolic Syndrome: A Systematic Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Treatment of type 2 diabetes and stress using neuro-emotional technique: case report.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The association between adverse childhood experiences (ACEs) and diabetes is unclear. This systematic review and meta-analysis aims to quantify the association between the number and types of ACEs and diabetes during adulthood based on available observational studies. Methods: A comprehensive literature search of studies exploring the association between ACEs and diabetes was conducted in PubMed, Medline, and Embase databases until 15 April 2022. A random-effects model was used to pool odds ratios (ORs) and 95% confidence intervals (CIs) for the number and types of ACEs with diabetes. Regarding the association between the number of ACEs and diabetes, we used funnel plots to examine publication bias, subgroup analysis to explore sources of heterogeneity, and sensitivity analysis to explore the robustness of the pooled results. Results: A total of 49 studies were included. Individuals with higher continuous ACEs (per each additional ACE: OR = 1.06, 95% CI = 1.02-1.10), any ACE (OR = 1.22, 95% CI = 1.16-1.28), or ≥4 ACEs (OR = 1.44, 95% CI = 1.27-1.63) were at an increased risk of diabetes in adulthood when compared with individuals without ACEs. Across specific ACE types, childhood economic adversity (OR = 1.11, 95% CI = 1.04-1.19), physical abuse (OR = 1.14, 95% CI = 1.07-1.21), sexual abuse (OR = 1.25, 95% CI = 1.12-1.39), verbal abuse (OR = 1.11, 95% CI = 1.03-1.20), and incarceration (OR = 1.22, 95% CI = 1.03-1.45) were associated with diabetes. However, neglect, emotional abuse, domestic violence, parental divorce or separation, parental death, and living with a family member with substance abuse or mental disorders were not significantly associated with diabetes. Conclusions: Individuals with ACEs may have a cumulative risk for diabetes in adulthood. It is critical to prevent ACEs and build resilience in individuals affected by ACEs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.