ArticlePloS one2022
Investigating sentence processing and working memory in patients with mild Alzheimer and elderly people.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Integrating acoustic, prosodic, and phonological features for automatic Alzheimer's detection.Frontiers in aging neuroscience · 2026Article
- Prefrontal activation and connectivity during verbal fluency in autism Spectrum disorder: an fNIRS study.Frontiers in human neuroscience · 2026Article
- Multi-level language deficits in behavioural frontotemporal degeneration and related disorders.Brain communications · 2026Article
- Dependency Grammar Approach to the Syntactic Complexity in the Discourse of Alzheimer Patients.Behavioral sciences (Basel, Switzerland) · 2025Article
- CogProg: Utilizing Large Language Models to Forecast In-the-moment Health Assessment.ACM transactions on computing for healthcare · 2025Article
- Screening for early Alzheimer's disease: enhancing diagnosis with linguistic features and biomarkers.Frontiers in aging neuroscience · 2024Article
- Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation.International journal of molecular sciences · 2023Article
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Abstract
introductionLinguistic disorders are one of the common problems in Alzheimer's disease, which in recent years has been considered as one of the key parameters in the diagnosis of Alzheimer (AD). Given that changes in sentence processing and working memory and the relationship between these two activities may be a diagnostic parameter in the early and preclinical stages of AD, the present study examines the comprehension and production of sentences and working memory in AD patients and healthy aged people.
methodsTwenty-five people with mild Alzheimer's and 25 healthy elderly people participated in the study. In this study, we used the digit span to evaluate working memory. Syntactic priming and sentence completion tasks in canonical and non-canonical conditions were used for evaluating sentence production. We administered sentence picture matching and cross-modal naming tasks to assess sentence comprehension.
resultsThe results of the present study revealed that healthy elderly people and patients with mild Alzheimer's disease have a significant difference in comprehension of relative clause sentences (P <0.05). There was no significant difference between the two groups in comprehension of simple active, simple active with noun phrase and passive sentences (P> 0.05). They had a significant difference in auditory and visual reaction time (P <0.05). Also there was a significant difference between the two groups in syntactic priming and sentence completion tasks. However, in non-canonical condition of sentence completion, the difference between the two groups was not significant (P> 0.05).
conclusionThe results of the present study showed that the mean scores related to comprehension, production and working memory in people with mild Alzheimer's were lower than healthy aged people, which indicate sentence processing problems at this level of the disease. People with Alzheimer have difficulty comprehending and producing complex syntactic structures and have poorer performance in tasks that required more memory demands. It seems that the processing problems of these people are due to both working memory and language problems, which are not separate from each other and both are involved in.
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