ArticlePLoS biology2022
The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons.
Article in PLoS biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Effectiveness of PsychobioticNutrients · 2024Trial
- The Effect of Microbiota and Evaluation of Released Cytokines in Schizophrenia Patients.Current microbiology · 2026Article
- The Gut Microbiome in Early Ontogeny: Implications for Brain and Immune System Development.Journal of developmental biology · 2026Review
- The gut microbiome shapes social behaviour across animal species.Nature reviews. Microbiology · 2026Review
- Society and the Microbiome: A Biopsychosocial Window Into Comprehensive Well-Being: A Review.Health science reports · 2026Article
- The Microbiota Shapes Central Nervous System Myelination in Early Life.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neuroplasticity mechanisms of NDBIs in autism: a review from brain connectivity to behavioral improvement.European journal of medical research · 2026Review
- Marginal link between sociality and gut microbiome in disparate mammalian hosts.FEMS microbes · 2026Article
- Environmental Microbial Cues Alter Embryonic Development and Stress Responses in Vertebrates: Insights From the Zebrafish (Danio rerio) Model.Molecular ecology · 2025Article
- A role for microglia in mediating the microbiota-gut-brain axis.Nature reviews. Immunology · 2025Review
- DRIVERS OF VARIATION OF THE ZEBRAFISH EGG MICROBIOME.bioRxiv : the preprint server for biology · 2025Article
- Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders.Translational psychiatry · 2025Review
- Development of a Short Telomere Zebrafish Model for Accelerated Aging Research and Antiaging Drug Screening.Aging cell · 2025Article
- Gut Microbiome Development in Rock Pigeons: Effects of Food Restriction Early in Life.Microorganisms · 2025Article
- Article
- How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells.Journal of neuroinflammation · 2025Review
- Article
- Neurodevelopmental Disorders Associated with Gut Microbiome Dysbiosis in Children.Children (Basel, Switzerland) · 2024Review
- Feeding strategy and feed protein level affect the gut microbiota of common carp (Cyprinus carpio).Environmental microbiology reports · 2024Article
- Something in the water: aquatic microbial communities influence the larval amphibian gut microbiota, neurodevelopment and behaviour.Proceedings. Biological sciences · 2024Article
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10 authors at 3 institutions in 3 countries.
Funding
Abstract
Host-associated microbiotas guide the trajectory of developmental programs, and altered microbiota composition is linked to neurodevelopmental conditions such as autism spectrum disorder. Recent work suggests that microbiotas modulate behavioral phenotypes associated with these disorders. We discovered that the zebrafish microbiota is required for normal social behavior and reveal a molecular pathway linking the microbiota, microglial remodeling of neural circuits, and social behavior in this experimentally tractable model vertebrate. Examining neuronal correlates of behavior, we found that the microbiota restrains neurite complexity and targeting of forebrain neurons required for normal social behavior and is necessary for localization of forebrain microglia, brain-resident phagocytes that remodel neuronal arbors. The microbiota also influences microglial molecular functions, including promoting expression of the complement signaling pathway and the synaptic remodeling factor c1q. Several distinct bacterial taxa are individually sufficient for normal microglial and neuronal phenotypes, suggesting that host neuroimmune development is sensitive to a feature common among many bacteria. Our results demonstrate that the microbiota influences zebrafish social behavior by stimulating microglial remodeling of forebrain circuits during early neurodevelopment and suggest pathways for new interventions in multiple neurodevelopmental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.