Evidence map›Paper›PMID 36318424›Full record

Trial reportAIDS and behavior2023

Does Problematic Substance Use Moderate Efficacy of Cognitive Behavioral Therapy for Adherence and Depression in HIV?

Jasmyn N Sanders, Tiffany R Glynn, Daniel Mayo, Sannisha K Dale, Audrey Harkness, Steven A Safren

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jasmyn N SandersDepartment of Psychology, University of Miami, Miami, USA.
Tiffany R GlynnDepartment of Psychology, University of Miami, Miami, USA.
Daniel MayoDepartment of Psychology, University of Miami, Miami, USA.
Sannisha K DaleDepartment of Psychology, University of Miami, Miami, USA.
Audrey HarknessDepartment of Public Health Sciences, University of Miami, Miami, USA.
Steven A SafrenDepartment of Psychology, University of Miami, Miami, USA. ssafren@miami.edu.ORCID http://orcid.org/0000-0002-0121-0806
University of Miami · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)Research Core & MHD-CEP30MH133399 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI Steven A Safren · 2023 to 2026
$8.9M
University of Miami Developmental HIV/AIDS Mental Health Research Center (D-ARC)P30MH116867 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2019 to 2023
$6.5M
Efficacy of CBT for Adherence and Depression in HIV Care SettingsR01MH084757 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SAFREN, STEVEN A · 2008 to 2012
$4.8M
Developing and Pilot Testing Peer Ambassador Stories for Increasing HIV-Prevention and Behavioral Health Treatment Uptake among Latino MSMK23MD015690 · NIMHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARKNESS, AUDREY · 2020 to 2025
$1.1M
Addressing psychosocial comorbidities in HIV treatment and preventionK24DA040489 · NIDA · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2016 to 2020
$931k
NIAID NIH HHS P30 AI042853NIAID NIH HHS P30 AI060354NIAID NIH HHS T32 AI007433NIDA NIH HHS K24 DA040489NIDA NIH HHS K24DA040489NIDA NIH HHS L60 DA059128NIMHD NIH HHS K23 MD015690NIMHD NIH HHS K23MD015690NIMH NIH HHS P30 MH116867NIMH NIH HHS P30MH11687NIMH NIH HHS P30 MH133399NIMH NIH HHS R01 MH084757
6 · The paper itself

Abstract

Problematic substance use may attenuate the effect of treating depression in people living with HIV (PLWH). We examined the potential moderating effect of problematic substance use on depression and adherence outcomes in PLWH (N = 143) who participated in a randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) and were randomized to either CBT-AD or enhanced treatment as usual (ETAU). Problematic substance use was operationalized as either having substance use-related diagnosis or current substance use in the past 30 days with a lifetime history of problematic use. Acute (baseline to 4-month) and follow up (4, 8, and 12-month) general linear modeling with time, condition, problematic baseline substance use, and corresponding interactions demonstrated that substance use did not significantly moderate the effects of CBT-AD on adherence or depression improvements. Therefore, CBT-AD was beneficial for PLWH with depression, regardless of problematic substance use when starting depression treatment. Based on these results, clinicians should not withhold CBT treatment for depression in patients with HIV and problematic substance use to attain reductions in depression and gains in adherence.

Indexed as

Cognitive Behavioral TherapyDepressionHIV InfectionsSubstance-Related DisordersHumansTreatment Adherence and ComplianceTreatment OutcomeDepressionHIVMedication adherenceSubstance use

Identifiers

PMID36318424
PMCPMC10150732
OpenAlexW4307848527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.