Evidence map›Paper›PMID 36318260›Full record

ArticleNucleic acids research2023

The Neuroscience Multi-Omic Archive: a BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain.

Seth A Ament, Ricky S Adkins, Robert Carter, Elena Chrysostomou, Carlo Colantuoni, Jonathan Crabtree, Heather H Creasy, Kylee Degatano, Victor Felix, Peter Gandt and 19 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
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  4. A Community Standard Multispecies Cell Atlas of the Basal Ganglia.bioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 4 institutions in 1 country.

Seth A AmentInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6443-7509
Ricky S AdkinsInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Robert CarterInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Elena ChrysostomouDepartment of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Carlo ColantuoniInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Jonathan CrabtreeInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Heather H CreasyInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-1369-6882
Kylee DegatanoData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Victor FelixInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Peter GandtInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Gwenn A GardenDepartment of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Michelle GiglioInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-7628-5565
Brian R HerbInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Farzaneh KhajoueiData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Elizabeth KiernanData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Carrie McCrackenInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Kennedy McDanielInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Suvarna NadendlaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Lance NickelInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Dustin OlleyInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-8685-0839
Joshua OrvisInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Joseph P ReceveurInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Mike SchorInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Shreyash SonthaliaDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Timothy L TickleData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-6592-6272
Jessica WayData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ronna HertzanoInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Anup A MahurkarInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Owen R WhiteInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · USBroad Institute · USJohns Hopkins University · USUniversity of North Carolina at Chapel Hill · US

Funding

A BRAIN Initiative Resource: The Neuroscience Multi-omic Data ArchiveR24MH114788 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI Anup Mahurkar, Owen R White · 2017 to 2026
$17.2M
NeMO Archive: SCORCH Support, Coordination and OutreachUM1DA052244 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI Seth Abrams Ament, Anup Mahurkar · 2020 to 2026
$10.2M
Illuminating Neurodevelopment through Integrated Analysis and Vizualization of Multi-Omic DataR24MH114815 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HERTZANO, RONNA, WHITE, OWEN R · 2018 to 2020
$2.3M
The gEAR portal - Advancing Data Sharing, Analysis and Discovery for Hearing and Balance ResearchR01DC019370 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI MAHURKAR, ANUP · 2021 to 2022
$1.5M
NIDA NIH HHS UM1 DA052244NIDCD NIH HHS R01 DC019370NIMH NIH HHS R24 MH114788NIMH NIH HHS R24 MH114815
6 · The paper itself

Abstract

Scalable technologies to sequence the transcriptomes and epigenomes of single cells are transforming our understanding of cell types and cell states. The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Cell Census Network (BICCN) is applying these technologies at unprecedented scale to map the cell types in the mammalian brain. In an effort to increase data FAIRness (Findable, Accessible, Interoperable, Reusable), the NIH has established repositories to make data generated by the BICCN and related BRAIN Initiative projects accessible to the broader research community. Here, we describe the Neuroscience Multi-Omic Archive (NeMO Archive; nemoarchive.org), which serves as the primary repository for genomics data from the BRAIN Initiative. Working closely with other BRAIN Initiative researchers, we have organized these data into a continually expanding, curated repository, which contains transcriptomic and epigenomic data from over 50 million brain cells, including single-cell genomic data from all of the major regions of the adult and prenatal human and mouse brains, as well as substantial single-cell genomic data from non-human primates. We make available several tools for accessing these data, including a searchable web portal, a cloud-computing interface for large-scale data processing (implemented on Terra, terra.bio), and a visualization and analysis platform, NeMO Analytics (nemoanalytics.org).

Indexed as

BrainDatabases, GeneticEpigenomicsMultiomicsTranscriptomeAnimalsGenomicsMammalsMicePrimates

Identifiers

PMID36318260
PMCPMC9825473
OpenAlexW4307846314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.