ArticleJAMA network open2022
Estimated Deaths Attributable to Excessive Alcohol Use Among US Adults Aged 20 to 64 Years, 2015 to 2019.
Article in JAMA network open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 3 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Computerized adaptive testing for assessing substance use and substance use disorder: A systematic review.Journal of substance use and addiction treatment · 2026Pooled it
- Effects of probiotics on liver function, inflammation, and gut microbiota in alcoholic liver injury: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Pooled it
- Associations between suicide ideation, craving, and alcohol use across 12 weeks of outpatient treatment for alcohol use disorder.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Trial
- Alcohol misuse and health-related behaviors among people with HIV during the COVID-19 stay-at-home directive: an ALIVE-Ex sub-study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Trial
- Ketone Supplementation Dampens Subjective and Objective Responses to Alcohol: Evidence From a Preclinical Rat Study and a Randomized, Cross-Over Trial in Healthy Volunteers.The international journal of neuropsychopharmacology · 2024Trial
- Use of an Automated Bilingual Digital Health Tool to Reduce Unhealthy Alcohol Use Among Latino Emergency Department Patients: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Employment insecurity and binge drinking in the United States: Implications of unemployment insurance.Preventive medicine · 2026Article
- Expectations versus reality: Associations among anticipated, natural environment, and laboratory-derived alcohol stimulation, sedation, and reward.Experimental and clinical psychopharmacology · 2026Article
- Trends in the Co-Occurrence of Alcohol Use and Cardiovascular Disease Among U.S. Adults, 1999 to 2023.JACC. Advances · 2026Article
- Daily state distress tolerance and alcohol use motivation among individuals with posttraumatic stress disorder symptoms who endorse hazardous alcohol use.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Reassessing alcohol consumption and cardiovascular disease by addressing bias in observational data: results from the Multi-Ethnic Study of Atherosclerosis.European journal of preventive cardiology · 2026Article
- Telehealth-Delivered Mindfulness-Based Intervention: Protocol for a Randomized Clinical Trial for Individuals With Alcohol Use Disorder.JMIR research protocols · 2026Article
- New Alcohol Warnings Outperform the Current U.S. Warning in a National Survey Experiment.Journal of studies on alcohol and drugs · 2026Article
- Narrowing differences in the rate of alcohol-related acute care admissions in the United States between women versus men, 2016-2023.Alcohol, clinical & experimental research · 2026Article
- Alcohol use disorder and use of rhythm control therapies in patients with atrial fibrillation: A nationwide cohort study.International journal of cardiology. Heart & vasculature · 2026Article
- Article
- Do Payment Methods Incentivize Screening for Unhealthy Alcohol Use in Ambulatory Care Settings? Evidence from the US National Ambulatory Medical Care Survey.The journal of behavioral health services & research · 2026Article
- Health impact of alcohol use in the USA: a protocol of a systematic review and modelling study.BMJ open · 2025Article
- Thinking when I'm drinking: The interaction of mood and rumination across drinking and non-drinking days.Journal of affective disorders · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: Alcohol consumption is a leading preventable cause of death in the US, and death rates from fully alcohol-attributable causes (eg, alcoholic liver disease) have increased in the past decade, including among adults aged 20 to 64 years. However, a comprehensive assessment of alcohol-attributable deaths among this population, including from partially alcohol-attributable causes, is lacking. Objective: To estimate the mean annual number of deaths from excessive alcohol use relative to total deaths among adults aged 20 to 64 years overall; by sex, age group, and state; and as a proportion of total deaths. Design, Setting, and Participants: This population-based cross-sectional study of mean annual alcohol-attributable deaths among US residents between January 1, 2015, and December 31, 2019, used population-attributable fractions. Data were analyzed from January 6, 2021, to May 2, 2022. Exposures: Mean daily alcohol consumption among the 2 089 287 respondents to the 2015-2019 Behavioral Risk Factor Surveillance System was adjusted using national per capita alcohol sales to correct for underreporting. Adjusted mean daily alcohol consumption prevalence estimates were applied to relative risks to generate alcohol-attributable fractions for chronic partially alcohol-attributable conditions. Alcohol-attributable fractions based on blood alcohol concentrations were used to assess acute partially alcohol-attributable deaths. Main Outcomes and Measures: Alcohol-attributable deaths for 58 causes of death, as defined in the Centers for Disease Control and Prevention's Alcohol-Related Disease Impact application. Mortality data were from the National Vital Statistics System. Results: During the 2015-2019 study period, of 694 660 mean deaths per year among adults aged 20 to 64 years (men: 432 575 [66.3%]; women: 262 085 [37.7%]), an estimated 12.9% (89 697 per year) were attributable to excessive alcohol consumption. This percentage was higher among men (15.0%) than women (9.4%). By state, alcohol-attributable deaths ranged from 9.3% of total deaths in Mississippi to 21.7% in New Mexico. Among adults aged 20 to 49 years, alcohol-attributable deaths (44 981 mean annual deaths) accounted for an estimated 20.3% of total deaths. Conclusions And Relevance: The findings of this cross-sectional study suggest that an estimated 1 in 8 total deaths among US adults aged 20 to 64 years were attributable to excessive alcohol use, including 1 in 5 deaths among adults aged 20 to 49 years. The number of premature deaths could be reduced with increased implementation of evidenced-based, population-level alcohol policies, such as increasing alcohol taxes or regulating alcohol outlet density.
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