Evidence map›Paper›PMID 36318175›Full record

ReviewACS applied bio materials2022

Sterilization of Polymeric Implants: Challenges and Opportunities.

Chloe K Herczeg, Jie Song

Abstract readReview
In one paragraph

Review in ACS applied bio materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chloe K HerczegDepartment of Orthopedics and Physical Rehabilitation, Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, United States.
Jie SongDepartment of Orthopedics and Physical Rehabilitation, Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, United States.ORCID 0000-0001-7554-5564

Funding

Synergistic anti-fouling coating and minimal systemic antibiotic injections for combating periprosthetic infectionsR01AR080431 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jie Song · 2022 to 2026
$2.8M
Micrococcal nuclease-triggered antibiotics release: a prophylactic implant coating against S. aureus infectionsR01AR078044 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SONG, JIE · 2020 to 2024
$2.4M
NIAMS NIH HHS R01 AR078044NIAMS NIH HHS R01 AR080431
6 · The paper itself

Abstract

Degradable and environmentally responsive polymers have been actively developed for drug delivery and regenerative medicine applications, yet inadequate consideration of their compatibility with terminal sterilization presents notable barriers to clinical translation. This Review discusses industry-established terminal sterilization methods and aseptic processing and contrasts them with innovative approaches aimed at preserving the integrity of polymeric implants. Regulatory guidelines, fiscal considerations, and potential pitfalls are discussed to encourage early integration of sterility regulatory considerations in material designs.

Indexed as

PolymersSterilizationProstheses and ImplantsSterilization, ReproductivePolymersaseptic processingdegradationoxidative damagepolymeric implantradicalsswellingterminal sterilization

Identifiers

PMID36318175
PMCPMC9691608

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.