Evidence map›Paper›PMID 36318025›Full record

Trial reportMicrobiology spectrum2022

The Effect of Amoxicillin with Clavulanate on the Microbiota of Tonsillar Tissue in Disease: a Randomized Control Trial.

James Johnston, Brett Wagner Mackenzie, Kristi Biswas, Sharon Waldvogel-Thurlow, Sita Tarini Clark, Fiona Radcliff, Murali Mahadevan, Richard G Douglas

Open access · goldAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Host microbiome-pathogen interactions in pediatric infections.Current opinion in infectious diseases · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

James JohnstonDepartment of Surgery, University of Aucklandgrid.9654.e, Auckland, New Zealand.
Brett Wagner MackenzieDepartment of Surgery, University of Aucklandgrid.9654.e, Auckland, New Zealand.ORCID 0000-0002-5318-1808
Kristi BiswasDepartment of Surgery, University of Aucklandgrid.9654.e, Auckland, New Zealand.
Sharon Waldvogel-ThurlowDepartment of Surgery, University of Aucklandgrid.9654.e, Auckland, New Zealand.
Sita Tarini ClarkDepartment of Surgery, University of Aucklandgrid.9654.e, Auckland, New Zealand.
Fiona RadcliffDepartment of Molecular Medicine and Pathology, University of Aucklandgrid.9654.e, Auckland, New Zealand.
Murali MahadevanDepartment of Surgery, University of Aucklandgrid.9654.e, Auckland, New Zealand.
Richard G DouglasDepartment of Surgery, University of Aucklandgrid.9654.e, Auckland, New Zealand.
University of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite antibiotics being the primary medical treatment for recurrent tonsillitis, the impact of antibiotics on the tonsillar microbiome is not well understood. This study aimed to determine the effect of amoxicillin with clavulanate on the composition and quantity of bacteria in the tonsils of children with recurrent tonsillitis. A multicenter randomized clinical trial in Auckland, New Zealand was undertaken between August 1, 2017, and June 30, 2018. Sixty children undergoing tonsillectomy for the indication of recurrent tonsillitis were recruited for this study. Following random allocation, 30 participants were prescribed amoxicillin with clavulanate for the week before surgery. The remaining 30 received no antibiotics. Immediately following surgery, the crypts of the right and left tonsils were swabbed. Bacterial 16S rRNA gene-targeted amplicon sequencing and histological techniques were utilized. In the control group, there were significantly higher relative abundances of Haemophilus, Streptococcus,

Indexed as

MicrobiotaTonsillitisAmoxicillinAnti-Bacterial AgentsChildClavulanic AcidHumansRNA, Ribosomal, 16SStreptococcus pyogenesAmoxicillinAnti-Bacterial AgentsClavulanic AcidRNA, Ribosomal, 16Samoxicillin with clavulanateantibioticsmicrobiotapediatricsrecurrent tonsillitistonsiltonsillectomy

Identifiers

PMID36318025
PMCPMC9769914
OpenAlexW4307846641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.