ArticlePediatrics2022
Optimizing Neurodevelopmental Outcomes in Neonates With Congenital Heart Disease.
Article in Pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 54 citations in OpenAlex.
- Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neurodevelopmental care across pediatric critical care settings: toward brain-focused critical care.European journal of pediatrics · 2026Review
- Circulating levels of growth differentiation factor-15 and its genetic variants -3148C>G (rs4808793) in pediatric cardiac patients.World journal of clinical pediatrics · 2026Article
- Neonatal Brain Network Integration Trajectories Predict Neurodevelopment in Congenital Heart Disease.medRxiv : the preprint server for health sciences · 2026Article
- Machine learning to infer neurocognitive testing scores among adolescents and young adults with congenital heart disease.Communications medicine · 2026Article
- Association between the gut microbiome and neurodevelopmental outcomes in infants with congenital heart disease: A prospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2026Article
- Placental vascular abnormality is associated with worse neurodevelopmental outcomes for infants with congenital heart disease and genetic abnormality.Early human development · 2026Article
- Global burden of developmental intellectual disability in children and adolescents with congenital heart disease, 1990-2021: a population-based study.Translational pediatrics · 2026Article
- Advances in interdisciplinary care for term and preterm neonates with congenital heart disease: a narrative review.European journal of pediatrics · 2026Review
- Perioperative mortality and 1-year neurodevelopmental outcome after cardiac surgery prior to 6 weeks of age, requiring perioperative extracorporeal membrane oxygenation in the first year of life.Frontiers in cardiovascular medicine · 2026Article
- Time-dependent responses of brain injury biomarkers after severe cerebral desaturation in paediatric patients during cardiac surgery with cardiopulmonary bypass: a single-centre observational cohort study.Frontiers in cardiovascular medicine · 2026Article
- Near-infrared spectroscopy cerebral oximetry in pediatric congenital heart disease with cardiopulmonary bypass: a narrative review of current evidence and neuroprotection.Frontiers in pediatrics · 2026Review
- Review
- Health-Related Quality of Life After Neonatal Treatment of Symptomatic Tetralogy of Fallot: Insights from the Congenital Cardiac Research Collaborative.Pediatric cardiology · 2025Article
- Placental and Fetal Brain Volumes in Congenital Heart Disease Are Smallest Among Fetuses With Genetic Abnormalities.Prenatal diagnosis · 2025Article
- Amplitude-Integrated/Continuous Electroencephalography for Early Detection of Low Cardiac Output After Chest Closure in an Infant.JACC. Case reports · 2025Article
- Long-term neurodevelopmental outcomes in children with hypoplastic left heart syndrome.Annals of medicine and surgery (2012) · 2025Review
- Neurodevelopmental follow-up care pathways and processes for children with congenital heart disease in Australia.Pediatric research · 2025Article
- Longitudinal magnetic resonance imaging reveals differences in cortical expansion in fetuses with congenital heart defects.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Impaired Cerebral Autoregulation in Children.Pediatric neurology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
Neurodevelopmental impairment is a common and important long-term morbidity among infants with congenital heart disease (CHD). More than half of those with complex CHD will demonstrate some form of neurodevelopmental, neurocognitive, and/or psychosocial dysfunction requiring specialized care and impacting long-term quality of life. Preventing brain injury and treating long-term neurologic sequelae in this high-risk clinical population is imperative for improving neurodevelopmental and psychosocial outcomes. Thus, cardiac neurodevelopmental care is now at the forefront of clinical and research efforts. Initial research primarily focused on neurocritical care and operative strategies to mitigate brain injury. As the field has evolved, investigations have shifted to understanding the prenatal, genetic, and environmental contributions to impaired neurodevelopment. This article summarizes the recent literature detailing the brain abnormalities affecting neurodevelopment in children with CHD, the impact of genetics on neurodevelopmental outcomes, and the best practices for neonatal neurocritical care, focusing on developmental care and parental support as new areas of importance. A framework is also provided for the infrastructure and resources needed to support CHD families across the continuum of care settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.