Evidence map›Paper›PMID 36317936›Full record

ArticlePest management science2022

Transforming the evaluation of agrochemicals.

Douglas C Wolf, Yadvinder Bhuller, Rhian Cope, Marco Corvaro, Richard A Currie, John Doe, Adriana Doi, Gina Hilton, Jyotigna Mehta, David Saltmiras and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Pest management science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 19 citations in OpenAlex.

  1. Key attributes of health and environmental risk decision-making: A scoping review.Risk analysis : an official publication of the Society for Risk Analysis · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 6 countries.

Douglas C WolfProduct Safety, Syngenta Crop Protection, Greensboro, NC, USA.ORCID https://orcid.org/0000-0003-1868-9574
Yadvinder BhullerExecutive Director's Office, Pest Management Regulatory Agency, Health Canada, Ottawa, ON, Canada.
Rhian CopeAustralian Pesticides and Veterinary Medicines Authority, Armidale, NSW, Australia.
Marco CorvaroRegulatory Toxicology, Human Safety, Corteva Agriscience, Rome, Italy.
Richard A CurrieProduct Safety Early Stage Research, Syngenta Crop Protection, Jealotts Hill, United Kingdom.ORCID https://orcid.org/0000-0002-6528-3326
John DoePharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
Adriana DoiRegulatory Science Crop Protection, BASF Crop Protection, Research Triangle Park, NC, USA.
Gina HiltonPETA Science Consortium International e.v, Stuttgart, Germany.ORCID https://orcid.org/0000-0003-2317-0072
Jyotigna MehtaADAMA Agricultural Solutions Ltd, Reading, UK.
David SaltmirasHuman Safety, Bayer CropScience, Chesterfield, MO, USA.
Fiona SewellToxicology and Regulatory Sciences, National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs), London, UK.
Maria TrainerAustralian Pesticides and Veterinary Medicines Authority, Armidale, NSW, Australia.
Sandrine E DéglinHealth and Environmental Sciences Institute, Washington, DC, USA.ORCID https://orcid.org/0000-0003-4393-5538
Australian Diabetes Society · AUAdama (Israel) · ILCorteva (United States) · USHealth and Environmental Sciences Institute · USHealth Canada · CALiverpool John Moores University · GBMalaria Consortium · GBNational Centre for the Replacement Refinement and Reduction of Animals in Research · GBNational Patient Safety Foundation · USResearch Triangle Park Foundation · USSyngenta (United Kingdom) · GBSyngenta (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present agrochemical safety evaluation paradigm is long-standing and anchored in well-established testing and evaluation procedures. However, it does not meet the present-day challenges of rapidly growing populations, food insecurity, and pressures from climate change. To transform the current framework and apply modern evaluation strategies that better support sustainable agriculture, the Health and Environmental Sciences Institute (HESI) assembled a technical committee to reframe the safety evaluation of crop-protection products. The committee is composed of international experts from regulatory agencies, academia, industry and nongovernmental organizations. Their mission is to establish a framework that supports the development of fit-for-purpose agrochemical safety evaluation that is applicable to changing global, as well as local needs and regulatory decisions, and incorporates relevant evolving science. This will be accomplished through the integration of state-of-the-art scientific methods, technologies and data sources, to inform safety and risk decisions, and adapt them to evolving local and global needs. The project team will use a systems-thinking approach to develop the tools that will implement a problem formulation and exposure driven approach to create sustainable, safe and effective crop protection products, and reduce, replace and refine animal studies with fit-for-purpose assays. A new approach necessarily will integrate the most modern tools and latest advances in chemical testing methods to guarantee the robust human and environmental safety and risk assessment of agrochemicals. This article summarizes the challenges associated with the modernization of agrochemical safety evaluation, proposes a potential roadmap, and seeks input and engagement from the broader community to advance this effort. © 2022 Health and Environmental Sciences Institute (HESI). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

AgrochemicalsCrop ProtectionAgricultureAnimalsHumansPest ControlRisk AssessmentAgrochemicalscrop protectionpesticiderisk assessmentsafety assessmenttesting

Identifiers

PMID36317936
PMCPMC9826516
OpenAlexW4293199784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.