Evidence map›Paper›PMID 36317876›Full record

ArticleInfection and immunity2022

IgaA Protein, GumB, Has a Global Impact on the Transcriptome and Surface Proteome of Serratia marcescens.

Nicholas A Stella, Eric G Romanowski, Kimberly M Brothers, Rachel C Calvario, Robert M Q Shanks

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. International journal of molecular sciences · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicholas A StellaDepartment of Ophthalmology, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh Pennsylvania, USA.
Eric G RomanowskiDepartment of Ophthalmology, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh Pennsylvania, USA.
Kimberly M BrothersDepartment of Ophthalmology, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh Pennsylvania, USA.
Rachel C CalvarioDepartment of Ophthalmology, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh Pennsylvania, USA.
Robert M Q ShanksDepartment of Ophthalmology, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh Pennsylvania, USA.ORCID 0000-0002-7699-5396
University of Pittsburgh · US

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ethan A Rossi · 1989 to 2026
$17.8M
NOT-NS-20-030: Use of anchored biologics to treat vesicant induced neovascularizationR01EY027331 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHANKS, ROBERT M · 2017 to 2021
$1.8M
Rise of lasR mutant Pseudomonas aeruginosa keratitisR01EY032517 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHANKS, ROBERT M · 2021 to 2024
$1.6M
NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY027331NEI NIH HHS R01 EY032517
6 · The paper itself

Abstract

Bacterial stress response signaling systems, like the Rcs system are triggered by membrane and cell wall damaging compounds, including antibiotics and immune system factors. These regulatory systems help bacteria survive envelope stress by altering the transcriptome resulting in protective phenotypic changes that may also influence the virulence of the bacterium. This study investigated the role of the Rcs stress response system using a clinical keratitis isolate of Serratia marcescens with a mutation in the

Indexed as

ProteomeSerratia marcescensBacterial ProteinsProteomicsTranscriptomeBacterial ProteinsProteomecytotoxicityfimbriaeIgaAkeratitismetalloproteasepiliRcs systemserralysinSerratia marcescensstress response

Identifiers

PMID36317876
PMCPMC9671016
OpenAlexW4307840610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.