Evidence map›Paper›PMID 36317291›Full record

ArticleAge and ageing2022

Developing a core outcome set for hospital deprescribing trials for older people under the care of a geriatrician.

Jacqueline Martin-Kerry, Jo Taylor, Sion Scott, Martyn Patel, David Wright, Allan Clark, David Turner, David Phillip Alldred, Katherine Murphy, Victoria Keevil and 3 more

Abstract read
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In one paragraph

Article in Age and ageing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jacqueline Martin-KerrySchool of Healthcare, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0002-9299-1360
Jo TaylorDepartment of Health Sciences, University of York, York YO10 5DD, UK.
Sion ScottSchool of Healthcare, University of Leicester, Leicester LE1 7RH, UK.
Martyn PatelNorfolk and Norwich University Hospital, Norwich NR4 7UY, UK.
David WrightSchool of Healthcare, University of Leicester, Leicester LE1 7RH, UK.
Allan ClarkNorwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.
David TurnerNorwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.
David Phillip AlldredSchool of Healthcare, University of Leeds, Leeds LS2 9JT, UK.
Katherine MurphyPatient and Public Involvement Lead, School of Healthcare, University of Leicester, Leicester, LE1 7RH, UK.
Victoria KeevilCambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.ORCID 0000-0001-6148-0640
Miles D WithamNewcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.
Ian KellarSchool of Psychology, University of Leeds, Leeds LS2 9JU, UK.
Debi BhattacharyaSchool of Healthcare, University of Leicester, Leicester LE1 7RH, UK.

Funding

Department of Health PGfAR 200,874
6 · The paper itself

Abstract

backgroundHalf of older people are prescribed unnecessary/inappropriate medications that are not routinely deprescribed in hospital hence there is a need for deprescribing trials. We aimed to develop a Core Outcome Set (COS) for deprescribing trials for older people under the care of a geriatrician during hospital admission.

methodsWe developed a list of potentially relevant outcomes from the literature. Using a two-round Delphi survey of stakeholder groups representing older people and carers, hospital clinicians, hospital managers, and ageing/deprescribing researchers, each outcome was scored according to Grading of Recommendations Assessment, Development and Evaluation, followed by two consensus workshops to finalise the COS.

resultsTwo hundred people completed Round 1 and 114 completed Round 2. Representing all stakeholder groups, 10 people participated in workshop 1 and 10 in workshop 2. Six outcomes were identified as most important, feasible and acceptable to collect in a trial: number of prescribed medicines stopped; number of prescribed medicines with dosage reduced; quality of life; mortality; adverse drug events and number of hospital stays. Three other outcomes were identified as important, but currently too burdensome to collect: number of potentially inappropriate medicines prescribed; burden from medication routine; and medication-related admissions to hospital.

conclusionsA COS represents the minimum outcomes that should be collected and reported. Whilst uncommon practice for COS development, the value of considering outcome collection feasibility is demonstrated by the removal of three potential outcomes that, if included, may have compromised COS uptake due to challenges with collecting the data.

Indexed as

DeprescriptionsGeriatriciansAgedDelphi TechniqueHospitalsHumansOutcome Assessment, Health CareQuality of Lifecore outcome setdeprescribinghospitalolder people

Identifiers

PMID36317291
PMCPMC9724769

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.