Evidence map›Paper›PMID 36317267›Full record

SynthesisInternational journal of geriatric psychiatry2022

Vascular disease and apathy symptoms in the very old: A cross-sectional and longitudinal meta-analysis of individual participant data.

Veerle M G T H van der Klei, Rosalinde K E Poortvliet, Jonathan M K Bogaerts, Jeanet W Blom, Simon P Mooijaart, Ruth Teh, Marama Muru-Lanning, Leah Palapar, Andrew Kingston, Louise Robinson and 2 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of geriatric psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Clinical Associations and Possible Risk Factors for Affective Neuropsychiatric Symptoms in Older Adults With and Without Cognitive Impairment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Article
  3. Apathy and Depression Impact on Cognitive Decline: Neuropsychological Specificities across Neurodegenerative Diseases.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Veerle M G T H van der KleiDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-2782-1517
Rosalinde K E PoortvlietDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Jonathan M K BogaertsDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Jeanet W BlomDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Simon P MooijaartDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Ruth TehSchool of Population Health, University of Auckland, Auckland, New Zealand.
Marama Muru-LanningSchool of Population Health, University of Auckland, Auckland, New Zealand.
Leah PalaparSchool of Population Health, University of Auckland, Auckland, New Zealand.
Andrew KingstonPopulation Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK.
Louise RobinsonPopulation Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, UK.ORCID 0000-0003-0209-2503
Ngaire KerseSchool of Population Health, University of Auckland, Auckland, New Zealand.
Jacobijn GusseklooDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NLUniversity of Auckland · NZNewcastle Hospitals - Campus for Ageing and Vitality · GB

Funding

Medical Research Council G0500997
6 · The paper itself

Abstract

objectivesPrevious findings suggest a vascular foundation underlying apathy, but transdiagnostic and prospective evidence on vascular apathy is scarce. This study examines the association between vascular disease and the presence and development of apathy symptoms in the very old.

methodsFour cohorts of the Towards Understanding Longitudinal International older People Studies (TULIPS)-consortium were included in a two-staged, individual participant data meta-analysis using generalized linear mixed models. Vascular disease was defined as a history of any clinical atherosclerotic pathology (angina pectoris, myocardial infarction, intermittent claudication, transient ischemic attack, stroke or related surgeries) and was related to apathy symptoms as repeatedly measured by the Geriatric Depression Scale (GDS-3A ≥2) over a maximum of 5 years.

resultsOf all 1868 participants (median age 85 years old), 53.9% had vascular disease and 44.3% experienced apathy symptoms. Participants with vascular disease had a 76% higher risk of apathy symptoms at baseline (odds ratio (OR) 1.76, 95% confidence interval (CI) 1.32-2.35), irrespective of depressive symptoms and only partially explained by stroke. Conversely, there was no association of vascular disease with the occurrence of apathy symptoms longitudinally, both in those with apathy at baseline (OR 1.00, 95% CI 0.84-1.20) and without (OR 0.96, 95% CI 0.84-1.09).

conclusionsVascular disease in the very old is associated with apathy symptoms cross-sectionally, but not proven longitudinally, independent of depressive symptoms. These findings query a vascular cause underlying apathy symptoms. However, the consistency of our cross-sectional findings in direction and magnitude across the TULIPS-consortium do emphasize international relevance of the interplay of vascular factors and apathy in advanced age, which meaning needs further unravelling.

Indexed as

ApathyIschemic Attack, TransientStrokeAgedAged, 80 and overCross-Sectional StudiesDepressionHumansProspective StudiesPsychiatric Status Rating Scalesatherosclerosismeta-analysisolder peopleprospectivevascular apathy

Identifiers

PMID36317267
PMCPMC9828503
OpenAlexW4306776778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.