ArticleiScience2022
Serum plays an important role in reprogramming the seasonal transcriptional profile of brown bear adipocytes.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Hibernating bear serum triggers an anti-fibrotic signature in human fibroblasts, involving ECM remodeling and MAPK signaling activation.Scientific reports · 2026Article
- Review
- A review on ecological and physiological studies in bears from a One Health perspective.The Journal of veterinary medical science · 2025Review
- Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus.Science (New York, N.Y.) · 2025Article
- The Role of Lipid Metabolic Reprogramming in the Hibernation of Chipmunks.Animals : an open access journal from MDPI · 2025Article
- Constitutive Differences in Immune Gene Expression Are Correlated With Wood Frog Populations From Contrasting Winter Environments.Molecular ecology · 2025Article
- Sugar assimilation underlying dietary evolution of Neotropical bats.Nature ecology & evolution · 2024Article
- Circadian gene transcription plays a role in cellular metabolism in hibernating brown bears, Ursus arctos.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Feeding during hibernation shifts gene expression toward active season levels in brown bears (Physiological genomics · 2023Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how metabolic reprogramming happens in cells will aid the progress in the treatment of a variety of metabolic disorders. Brown bears undergo seasonal shifts in insulin sensitivity, including reversible insulin resistance in hibernation. We performed RNA-sequencing on brown bear adipocytes and proteomics on serum to identify changes possibly responsible for reversible insulin resistance. We observed dramatic transcriptional changes, which depended on both the cell and serum season of origin. Despite large changes in adipocyte gene expression, only changes in eight circulating proteins were identified as related to the seasonal shifts in insulin sensitivity, including some that have not previously been associated with glucose homeostasis. The identified serum proteins may be sufficient for shifting hibernation adipocytes to an active-like state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.