ReviewTherapeutic advances in musculoskeletal disease2022
Bone fragility: conceptual framework, therapeutic implications, and COVID-19-related issues.
Review in Therapeutic advances in musculoskeletal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Association of osteoporotic fractures of femoral neck and femoral neck geometric parameters in native Chinese women.BMC musculoskeletal disorders · 2024Article
- Therapeutic advantage of teriparatide in very elderly patients with proximal femoral fractures: a functional and BMD analysis.BMC musculoskeletal disorders · 2024Article
- Bridging the Gap: Pregnancy-And Lactation-Associated Osteoporosis.Diagnostics (Basel, Switzerland) · 2023Review
- Quantitative CT screening improved lumbar BMD evaluation in older patients compared to dual-energy X-ray absorptiometry.BMC geriatrics · 2023Article
- Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients.Therapeutic advances in musculoskeletal disease · 2023Review
- Anti-sclerostin antibodies: a new frontier in fragility fractures treatment.Therapeutic advances in musculoskeletal disease · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Bone fragility is the susceptibility to fracture even for common loads because of structural, architectural, or material alterations of bone tissue that result in poor bone strength. In osteoporosis, quantitative and qualitative changes in density, geometry, and micro-architecture modify the internal stress state predisposing to fragility fractures. Bone fragility substantially depends on the structural behavior related to the size and shape of the bone characterized by different responses in the load-deformation curve and on the material behavior that reflects the intrinsic material properties of the bone itself, such as yield and fatigue. From a clinical perspective, the measurement of bone density by DXA remains the gold standard for defining the risk of fragility fracture in all population groups. However, non-quantitative parameters, such as macro-architecture, geometry, tissue material properties, and microcracks accumulation can modify the bone's mechanical strength. This review provides an overview of the role of different contributors to bone fragility and how these factors might be influenced by the use of anti-osteoporotic drugs and by the COVID-19 pandemic.
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Registered trials
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