Evidence map›Paper›PMID 36316972›Full record

ArticleEthics & human research2022

Participants' Perspectives on Payment for Research Participation: A Qualitative Study.

Emily A Largent, Whitney Eriksen, Frances K Barg, S Ryan Greysen, Scott D Halpern

Registry-linked trialAbstract read
In one paragraph

Article in Ethics & human research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05554601 (A Randomized Trial of Behaviorally Designed Gamification and Social Incentives to Increase Physical Activity Among Overweight and Obese Veterans), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05554601 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

A Randomized Trial of Behaviorally Designed Gamification and Social Incentives to Increase Physical Activity Among Overweight and Obese Veterans

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2023 to 2027Enrolled725ConditionsHypertension, ObesityArmsgamification with collaboration, gamification with competition
3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
  2. The impact of learning about financial compensation on enrollment in Alzheimer's disease longitudinal research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Trial
  3. Trial
  4. Randomized Comparison of Online Motivational Themes in Clinical Trial Recruitment.Circulation. Cardiovascular quality and outcomes · 2025
    Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Study partners' views on remuneration in longitudinal Alzheimer's disease research.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emily A LargentBioethicist in the Department of Medical Ethics and Health Policy at the University of Pennsylvania Perelman School of Medicine.
Whitney EriksenQualitative researcher in the Department of Family Medicine and Community Health at the University of Pennsylvania Perelman School of Medicine.
Frances K BargMedical anthropologist in the Department of Family Medicine and Community Health at the University of Pennsylvania Perelman School of Medicine.
S Ryan GreysenHospitalist and health services researcher in the Section of Hospital Medicine at the Center for Evidence-Based Practice at the University of Pennsylvania Perelman School of Medicine.
Scott D HalpernIntensivist and health services researcher in the Department of Medicine and the Department of Medical Ethics and Health Policy at the University of Pennsylvania Perelman School of Medicine.

Funding

Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8M
A Randomized Trial of Incentives for Research ParticipationR01CA197332 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HALPERN, SCOTT D · 2015 to 2019
$2.9M
Improving the fairness of RCTs among patients with acute and chronic respiratory failureK24HL143289 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Scott D Halpern · 2018 to 2026
$1.1M
NCI NIH HHS R01 CA197332NCI NIH HHS R01CA197332NHLBI NIH HHS K24 HL143289NIA NIH HHS P30 AG072979
6 · The paper itself

Abstract

Investigators commonly offer payments to research participants to promote recruitment and retention. Yet the ethics of offering monetary incentives to research participants continues to be debated. Prior conceptual work has addressed some of these concerns; there is, however, also a need for empirical evidence to understand the effects of payment on participants. Here, we report the results of a qualitative study comprising (1) discourse analysis of recruitment conversations between study coordinators and potential participants for an actual clinical trial and (2) semistructured interviews with participants addressing the effects of an incentive on their decision-making. Many participants reported that money had been a motivation for enrolling in the clinical trial but did not use reasoning that suggested undue influence or unjust inducement. These findings add to a growing body of literature suggesting that payment is an ethically acceptable tool for promoting recruitment and retention in clinical trials.

Indexed as

MotivationResearch SubjectsClinical Trials as TopicHumansQualitative Researchcoercionhuman research ethicsinformed consentpaymenttherapeutic misconceptionundue influence

Identifiers

PMID36316972
PMCPMC9631331

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.