ArticleRespiratory research2022
Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity.
Article in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Association of preserved ratio impaired spirometry with mortality and cardiovascular diseases: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Trajectory of preserved ratio impaired spirometry (PRISm): patterns, predictors, and potential interventions.Clinical and experimental medicine · 2026Review
- Application of the Forced Oscillation Technique in Patients With Preserved Ratio Impaired Spirometry.Cureus · 2026Article
- Small airways dysfunction: associated factors, clinical aspects and new perspectives.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Prevalence of PRISm and COPD and associated factors in a university medical centre spirometry unit: a cross-sectional analysis.BMJ open · 2026Article
- Phenotyping preserved ratio impaired spirometry (PRISm) using quantitative high-resolution computed tomography imaging features.Quantitative imaging in medicine and surgery · 2026Article
- Asthma outcomes in adults with preserved ratio impaired spirometry: a cohort study.ERJ open research · 2026Article
- Dietary quality, insulin resistance, and preserved ratio impaired spirometry in postmenopausal women: a cross-sectional study with exploratory mediation analysis.Frontiers in nutrition · 2026Article
- Biphasic quantitative CT to classify a residual volume-defined subclinical gas-trapping phenotype: development and internal validation of a multivariable model.Journal of thoracic disease · 2025Article
- Oscillometry findings in altered spirometry patterns and relationship to respiratory symptoms.ERJ open research · 2025Article
- Comprehensive Review of Comorbidities in Chronic Obstructive Pulmonary Disease and Preserved Ratio Impaired Spirometry: Insights from 2024.Tuberculosis and respiratory diseases · 2025Article
- Assessment of Small Airways Function in Eosinophilic Preserved Ratio Impaired Spirometry.Pulmonary therapy · 2025Article
- Addressing Knowledge Gaps in the Early Detection of Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- The Application of Ultrasonography in the Detection of Airway Obstruction: A Promising Area of Research or Unnecessary Gadgetry?Life (Basel, Switzerland) · 2025Review
- Article
- Regional lung function assessment using electrical impedance tomography in COPD, PRISm, and normal spirometry subjects: insights into early diagnostic potential.BMC pulmonary medicine · 2025Article
- Lung function decline and incidence of chronic obstructive pulmonary disease in participants with spirometry-defined small airway dysfunction: a 15-year prospective cohort study in China.Respiratory research · 2025Article
- Metabolic syndrome, small airway dysfunction and the mediating role of inflammation.Scientific reports · 2025Article
- The Role of Impulse Oscillometry in Detection of Preserved Ratio Impaired Spirometry (PRISm).Advances in respiratory medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
backgroundPreserved ratio impaired spirometry (PRISm) refers to decreased forced expiratory volume in 1 s (FEV
methodsWe conducted a cross-sectional community-dwelling study in China. Demographic data, standard respiratory epidemiology questionnaire, spirometry, impulse oscillometry (IOS) and computed tomography (CT) data were collected. PRISm was defined as post-bronchodilator FEV
resultsThe final analysis included 1439 subjects. PRISm had higher odds and more severity in spirometry-defined SAD (pre-bronchodilator: odds ratio [OR]: 5.99, 95% confidence interval [95%CI]: 3.87-9.27, P < 0.001; post-bronchodilator: OR: 14.05, 95%CI: 8.88-22.24, P < 0.001), IOS-defined SAD (OR: 2.89, 95%CI: 1.82-4.58, P < 0.001), and CT-air trapping (OR: 2.01, 95%CI: 1.08-3.72, P = 0.027) compared with healthy control after adjustment for confounding factors. CT-measured total lung capacity in PRISm was lower than that in healthy controls (4.15 ± 0.98 vs. 4.78 ± 1.05 L, P < 0.05), after adjustment. These results were robust in repeating analyses and subgroup analyses.
conclusionOur finding revealed that PRISm was associated with SAD and reduced total lung capacity. Future studies to identify the underlying mechanisms and longitudinal progression of PRISm are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.