Evidence map›Paper›PMID 36316642›Full record

ArticleCancer biology & therapy2022

STEAP2 promotes osteosarcoma progression by inducing epithelial-mesenchymal transition via the PI3K/AKT/mTOR signaling pathway and is regulated by EFEMP2.

Dong Zhang, Haitao Liu, Weihua Wang, Gang Xu, Chenxiao Yin, Songgang Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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  8. The role of kinesin superfamily proteins in hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2024
    Review
  9. Bladder cancer: non-coding RNAs and exosomal non-coding RNAs.Functional & integrative genomics · 2024
    Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dong ZhangDepartment of Orthopedics, Suzhou Hospital of Anhui Medical University, Suzhou, P.R. China.
Haitao LiuDepartment of Orthopedics, Xiangcheng No. 2 People's Hospital, Suzhou, P.R. China.
Weihua WangDepartment of Orthopedics, Xiangcheng No. 2 People's Hospital, Suzhou, P.R. China.
Gang XuDepartment of Orthopedics, Xiangcheng No. 2 People's Hospital, Suzhou, P.R. China.
Chenxiao YinDepartment of Orthopedics, Xiangcheng No. 2 People's Hospital, Suzhou, P.R. China.
Songgang WangDepartment of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.ORCID 0000-0002-7554-9087
Anhui Medical University · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was designed to explore the prognostic significance and functionality of STEAP2 (six-transmembrane epithelial antigen of prostate 2) in osteosarcomas and determine whether EFEMP2 (Epidermal growth factor-containing fibulin-like extracellular matrix protein 2) targets STEAP2 to facilitate osteosarcoma cell infiltration and migration. STEAP2 expression in peritumoral tissues, osteosarcoma, benign fibrous dysplasia, osteosarcoma cells, normal osteoblastic hFOB cells, and various invasive subclones was evaluated using IHC, ICC, and qRT-PCR. We also evaluated the association between STEAP2 expression and disease outcome using Kaplan-Meier analyses and then investigated STEAP2 regulation and its functional effects using both

Indexed as

Bone NeoplasmsEpithelial-Mesenchymal TransitionExtracellular Matrix ProteinsOsteosarcomaOxidoreductasesCell Line, TumorCell MovementCell ProliferationHumansPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesEFEMP2 protein, humanExtracellular Matrix ProteinsMTOR protein, humanOxidoreductasesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSTEAP2 protein, humanTOR Serine-Threonine KinasesEMTinvasionmetastasisosteosarcomaPI3K/AKT/mTOR signaling pathwaySTEAP2

Identifiers

PMID36316642
PMCPMC9629848
OpenAlexW4308024967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.