ReviewJournal of muscle research and cell motility2023
Utility of the burmese Python as a model for studying plasticity of extreme physiological systems.
Review in Journal of muscle research and cell motility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Beyond canonical homeostasis: Dynamic, plastic, and intermittently unregulated physiology as the norm.Physiological reports · 2026Review
- Multi-omics insight into cardiac myofibril remodeling in post-prandial Burmese pythons.Communications biology · 2026Article
- Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway.Nature metabolism · 2026Article
- Snake postprandial metabolite shows cross-species activation of hypothalamic neurons.Nature metabolism · 2026Article
- Multi-omics Insight into Cardiac Myofibril Remodeling in Post-Prandial Burmese Pythons.bioRxiv : the preprint server for biology · 2026Article
- Genome report: first whole genome assembly of Python regius (ball python), a model of extreme physiological and metabolic plasticity.G3 (Bethesda, Md.) · 2025Article
- Animal Models of Human Disease 2.0.International journal of molecular sciences · 2024Article
- Molecular regulation of reversible cardiac remodeling: lessons from species with extreme physiological adaptations.The Journal of experimental biology · 2024Review
- Regression of postprandial cardiac hypertrophy in burmese pythons is mediated by FoxO1.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hearts apart: sex differences in cardiac remodeling in health and disease.The Journal of clinical investigation · 2024Review
- Prairie voles as a model for adaptive reward remodeling following loss of a bonded partner.Annals of the New York Academy of Sciences · 2024Review
- A Conserved Mechanism of Cardiac Hypertrophy Regression through FoxO1.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Non-traditional animal models present an opportunity to discover novel biology that has evolved to allow such animals to survive in extreme environments. One striking example is the Burmese python (Python molurus bivittatus), which exhibits extreme physiological adaptation in various metabolic organs after consuming a large meal following long periods of fasting. The response to such a large meal in pythons involves a dramatic surge in metabolic rate, lipid overload in plasma, and massive but reversible organ growth through the course of digestion. Multiple studies have reported the physiological responses in post-prandial pythons, while the specific molecular control of these processes is less well-studied. Investigating the mechanisms that coordinate organ growth and adaptive responses offers the opportunity to gain novel insight that may be able to treat various pathologies in humans. Here, we summarize past research on the post-prandial physiological changes in the Burmese python with a focus on the gastrointestinal tract, heart, and liver. Specifically, we address our recent molecular discoveries in the post-prandial python liver which demonstrate transient adaptations that may reveal new therapeutic targets. Lastly, we explore new biology of the aquaporin 7 gene that is potently upregulated in mammalian cardiac myocytes by circulating factors in post-prandial python plasma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.