ArticleGenome research
Direct detection of natural selection in Bronze Age Britain.
Article in Genome research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global Genetic Variation in Circulating 25-Hydroxyvitamin D: A Systematic Review of GWAS Evidence Across Different Ancestral Groups.Nutrients · 2026Pooled it
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Insights into human adaptation from ancient DNA.Nature genetics · 2026Review
- The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Assessing Ancient DNA Sampling Strategies for Natural Selection Inference in Humans Using Allele Frequency Time Series Data.Genome biology and evolution · 2026Article
- Global patterns of natural selection inferred using ancient DNA.bioRxiv : the preprint server for biology · 2026Article
- A SNP panel for co-analysis of capture and shotgun ancient DNA data.bioRxiv : the preprint server for biology · 2025Article
- Article
- Multiple-testing corrections in selection scans using identity-by-descent segments.American journal of human genetics · 2025Article
- The persistence and loss of hard selective sweeps amid ancient human admixture.bioRxiv : the preprint server for biology · 2025Article
- Estimating allele frequencies, ancestry proportions and genotype likelihoods in the presence of mapping bias.G3 (Bethesda, Md.) · 2025Article
- Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes.Nature genetics · 2025Article
- Article
- diplo-locus: a lightweight toolkit for inference and simulation of time-series genetic data under general diploid selection.G3 (Bethesda, Md.) · 2025Article
- A novel expectation-maximization approach to infer general diploid selection from time-series genetic data.PLoS genetics · 2025Article
- Inferring fitness seascapes from evolutionary histories.bioRxiv : the preprint server for biology · 2025Article
- A novel expectation-maximization approach to infer general diploid selection from time-series genetic data.bioRxiv : the preprint server for biology · 2025Article
- diplo-locus: A lightweight toolkit for inference and simulation of time-series genetic data under general diploid selection.bioRxiv : the preprint server for biology · 2025Article
- Evaluating ARG-estimation methods in the context of estimating population-mean polygenic score histories.Genetics · 2025Article
- Sparse haplotype-based fine-scale local ancestry inference at scale reveals recent selection on immune responses.Nature communications · 2025Article
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2 authors.
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Abstract
We developed a novel method for efficiently estimating time-varying selection coefficients from genome-wide ancient DNA data. In simulations, our method accurately recovers selective trajectories and is robust to misspecification of population size. We applied it to a large data set of ancient and present-day human genomes from Britain and identified seven loci with genome-wide significant evidence of selection in the past 4500 yr. Almost all of them can be related to increased vitamin D or calcium levels, suggesting strong selective pressure on these or related phenotypes. However, the strength of selection on individual loci varied substantially over time, suggesting that cultural or environmental factors moderated the genetic response. Of 28 complex anthropometric and metabolic traits, skin pigmentation was the only one with significant evidence of polygenic selection, further underscoring the importance of phenotypes related to vitamin D. Our approach illustrates the power of ancient DNA to characterize selection in human populations and illuminates the recent evolutionary history of Britain.
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