Evidence map›Paper›PMID 36316073›Full record

ArticleBMJ open2022

Data-informed stepped care to improve youth engagement in HIV care in Kenya: a protocol for a cluster randomised trial of a health service intervention.

Pamela Kohler, Kawango Agot, Irene N Njuguna, Jessica Dyer, Jacinta Badia, Wenwen Jiang, Kristin Beima-Sofie, Nok Chhun, Irene Inwani, Seema K Shah and 3 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05007717 (Data-informed Stepped Care), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05007717 nacompletednot on this map

Data-informed Stepped Care (DiSC) to Improve Adolescent HIV Outcomes (UH3)

TypeinterventionalSponsorUniversity of WashingtonRan2022 to 2023Enrolled1,911ConditionsAdolescent Behavior, HivArmsData-informed Stepped Care (DiSC)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Pamela KohlerChild, Family, and Population Health Nursing, University of Washington, Seattle, Washington, USA pkohler2@uw.edu.
Kawango AgotImpact Research and Development Organisation, Kisumu, Kenya.
Irene N NjugunaGlobal Health, University of Washington, Seattle, Washington, USA.
Jessica DyerGlobal Health, University of Washington, Seattle, Washington, USA.
Jacinta BadiaImpact Research and Development Organisation, Kisumu, Kenya.
Wenwen JiangEpidemiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-0579-9443
Kristin Beima-SofieGlobal Health, University of Washington, Seattle, Washington, USA.
Nok ChhunGlobal Health, University of Washington, Seattle, Washington, USA.
Irene InwaniPediatrics, Kenyatta National Hospital, Nairobi, Kenya.
Seema K ShahPediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Barbra A RichardsonGlobal Health, Biostatistics, University of Washington, Seattle, Washington, USA.
Nahida ChaktouraEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Washington, District of Columbia, USA.
Grace John-StewartGlobal Health, Epidemiology, Pediatrics, Medicine, University of Washington, Seattle, Washington, USA.
University of Washington · USImpact Research and Development Organization · KEKenyatta National Hospital · KENational Institutes of Health · USNorthwestern University · US

Funding

Data-informed Stepped Care (DiSC) to Improve Adolescent HIV OutcomesUH3HD096906 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C., KOHLER, PAMELA · 2020 to 2022
$3.1M
Data-informed Stepped Care (DiSC) to Improve Adolescent HIV OutcomesUG3HD096906 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C., KOHLER, PAMELA · 2018 to 2019
$1.9M
NICHD NIH HHS UG3 HD096906NICHD NIH HHS UH3 HD096906
6 · The paper itself

Abstract

introductionAdolescents and youth living with HIV (AYLHIV) have lower retention in care, adherence to treatment, and viral suppression compared with adults. Stepped care is a process by which clients are assigned to increasingly intensive services or 'steps' according to level of need. Differentiated care, in which stable clients access less frequent services, can be combined with stepped care to align needs and preferences of youth to promote optimal engagement in care. METHODS AND ANALYSIS: This hybrid type I effectiveness implementation cluster randomised trial aims to evaluate a data-informed stepped care (DiSC) intervention for AYLHIV. AYLHIV ages 10-24 receiving care at 24 HIV treatment facilities in Kisumu, Homabay and Migori counties in Kenya will be enrolled. Twelve facilities will be randomised to the DiSC intervention, and 12 will provide standard care. A clinical assignment tool developed by the study team will be used at intervention sites to assign AYLHIV to one of four steps based on risk for loss to follow-up: differentiated care, standard care, counselling services or intensive support services. The primary clinical outcome is retention in care, specifically missed visits (failure to return within 30 days for any visit) and 12-month loss to follow-up. Implementation outcomes are based on the Reach, Effectiveness, Adoption, Implementation and Maintenance framework. Proportions of missed visits will be compared using mixed effect models clustered by facility and participant. ETHICS AND DISSEMINATION: This study has been approved by the University of Washington Institutional Review Board (STUDY00011096), Maseno University Ethical Review Committee (MUERC/00917/20) and the Kenya National Commission for Science, Technology and Innovation (444824). AYLHIV provide written informed consent when legally permitted, or assent with caregiver permission for minors. Study staff will work with a Community Advisory Board, including youth members, to disseminate results via discussions, presentations, journal publications and local or international conferences. TRIAL REGISTRATION NUMBER: NCT05007717.

Indexed as

HIV InfectionsResearch DesignAdolescentAdultCaregiversChildCounselingHumansKenyaRandomized Controlled Trials as TopicYoung AdultClinical trialsCommunity child healthHIV & AIDSPaediatric intensive & critical careQuality in health care

Identifiers

PMID36316073
PMCPMC9628651
OpenAlexW4307697643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.