ArticleBMJ open quality2022
Sociodemographic and psychological characteristics influencing patients' willingness to participate in clinical trials.
Article in BMJ open quality, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
34 citing papers in PubMed, 36 citations in OpenAlex.
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- Factors Affecting Acceptance of Participating in Clinical Trials of New Drugs: A National Cross-Sectional Study.Journal of evidence-based medicine · 2026Article
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- Reach and representativeness within a rural randomized controlled trial designed to improve community health through civic engagement for built environment change in Texas and New York.Wellbeing, space and society · 2026Article
- Baseline self-efficacy and engagement in a symptom management intervention after cancer treatment: an exploratory analysis of a sequential multiple assignment randomized trial.Journal of cancer survivorship : research and practice · 2026Article
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- University students' interest in intervention research participation is associated with gender, age and symptoms of depression, general and social anxiety, panic disorder and self-harm.BMC research notes · 2026Article
- Clinical trials in rheumatology: patient motivations and concerns as key determinants of recruitment.Reumatologia · 2026Review
- Assessment of Participant Satisfaction and Overall Experience: A Cross-Sectional Survey to Inform Trial Conduct.Patient preference and adherence · 2026Article
- A study on the prevalence and influencing factors of the willingness of healthy subjects to participate in clinical trials.Frontiers in public health · 2026Article
- Doxycycline Postexposure Prophylaxis Is Effective and Highly Acceptable in an Urban Public Sexually Transmitted Disease Clinic: Philadelphia, 2019-2023.Sexually transmitted diseases · 2025Article
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- Failure to complete diagnostic testing in patients with suspected obstructive sleep apnoea and inconclusive home sleep apnoea test.Sleep & breathing = Schlaf & Atmung · 2025Article
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- The participants' perspective on facioscapulohumeral muscular dystrophy trials in The Netherlands - A qualitative study.Journal of neuromuscular diseases · 2025Article
- Prasinezumab slows motor progression in Parkinsons disease: beyond the clinical data.NPJ Parkinson's disease · 2025Review
- Clinical Trial Participation Motivation: Role of Smoking Status.Healthcare (Basel, Switzerland) · 2025Article
- "I'm tired of seeing my friends die": Barriers and facilitators to participating in clinical trials among rural people who use drugs in the United States.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
- Perceptions and attitudes toward clinical trial participation: a study onFrontiers in pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsClinical trials are fundamental for the development of new medicines and patient participation is based on free consent. Our study sought to identify psychological characteristics that may influence patient willingness to participate in a clinical trial.
methodsA total of 100 participants were invited to participate with 80% positive response rate. The psychological characteristics of each patient were evaluated using the following validated psychometric scales: Self-Efficacy Scale, Curiosity, Exploration Inventory-Trait, Social Support Satisfaction, State-Trait Anxiety Inventory and Social Avoidance and Distress, and Fear of Negative Evaluation.
resultsPatients who agreed to participate in the clinical trial were significantly younger than those who refused (p=0.028). There were no differences in sex, lifestyle, employment status, monthly income or education. After adjusting for age and sex, patients who agreed to participate scored significantly higher in the following: self-efficacy total score (p<0.001), effectiveness in adversity (p<0.001), social effectiveness (p<0.001) and initiation and persistence (p<0.001); social support total score (p<0.001), family satisfaction (p=0.015), friendship satisfaction (p<0.001), social activities satisfaction (p=0.002) and intimacy (p<0.001); total curiosity score (p<0.001), absorption (p<0.001) and exploration (p<0.001). Compared with patients who agreed to participate, those who refused scored significantly higher for both state (p<0.001) and trait anxiety (p<0.001), fear of negative evaluation (p<0.001) and social avoidance and distress (p<0.001).
conclusionsPatients who were willing to participate in clinical trials exhibited different psychological characteristics to patients who refused. Specifically, they were more curious and self-efficacious, less anxious and reported a higher level of social support than patients who declined to participate. Identifying characteristics that condition the individual's decision to participate in a clinical trial has important implications for the development of patient-focused communication strategies and improved recruitment approaches.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.