ArticleJournal of the American Chemical Society2022
Palladium Hydride-Enabled Hydroalkenylation of Strained Molecules.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Fluorinated 4‑Methylideneisoxazolidin-5-ones: Synthesis and Apoptosis-Inducing Antiproliferative Activity.ACS medicinal chemistry letters · 2026Article
- Palladium-Catalyzed Fluoroallylation of Aldimine Esters With gem-Difluorocyclopropanes: Synthesis of Fluorinated α-Amino Acid Derivatives.Chemistry, an Asian journal · 2026Article
- Accessing Long-Lived, Highly Stable Phosphine-Ligand-Free Palladium Hydrides via Palladium-Micelle Synergy.Journal of the American Chemical Society · 2026Article
- Enantioconvergent vinylcyclopropane-cyclopentene rearrangement with vessel-controlled chemodivergence.Nature chemistry · 2026Article
- Influence of Hydrogen-Incorporation on the Bulk Electronic Structure and Chemical Bonding in Palladium.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Catalytic asymmetric functionalization of bicyclo[1.1.0]butane boronic esters enabled by 1,2-oxygen migration.Nature communications · 2026Article
- Article
- Diastereoselective synthesis of multi-substituted cyclobutanes via catalyst-controlled regiodivergent hydrophosphination of acyl bicyclobutanes.Nature communications · 2025Article
- Regiodivergent hydrophosphination of Bicyclo[1.1.0]-Butanes under catalyst control.Nature communications · 2025Article
- Photoinduced cobaloxime catalysis enabled dehydrogenative C2-phosphinylation of bicyclo[1.1.0]butanes to access phosphorylated cyclobutenes.RSC advances · 2025Article
- Catalysis in the Excited State: Bringing Innate Transition Metal Photochemistry into Play.ACS catalysis · 2025Review
- Illuminating Palladium Catalysis.Accounts of chemical research · 2025Article
- Asymmetric synthesis of atropisomers featuring cyclobutane boronic esters facilitated by ring-strained B-ate complexes.Nature communications · 2024Article
- Strain-enabled radical spirocyclization cascades: rapid access to spirocyclobutyl lactones and - lactams.Chemical science · 2024Article
- Recent Advances in Visible Light Induced Palladium Catalysis.Angewandte Chemie (International ed. in English) · 2024Review
- Bridge Cross-Coupling of Bicyclo[1.1.0]butanes.Organic letters · 2024Article
- Stereoselective Alder-Ene Reactions of Bicyclo[1.1.0]butanes: Facile Synthesis of Cyclopropyl- and Aryl-Substituted Cyclobutenes.Journal of the American Chemical Society · 2024Article
- Photochemical α-selective radical ring-opening reactions of 1,3-disubstituted acyl bicyclobutanes with alkyl halides: modular access to functionalized cyclobutenes.Chemical science · 2023Article
- Escape from Hydrofunctionalization: Palladium Hydride-Enabled Difunctionalization of Conjugated Dienes and Enynes.Angewandte Chemie (International ed. in English) · 2023Article
- A Chemoselective Polarity-Mismatched Photocatalytic C(spAngewandte Chemie (International ed. in English) · 2023Article
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Authors and funding
2 authors.
Funding
Abstract
We report the first palladium hydride enabled hydroalkenylation of strained molecules. This new mild protocol proceeds via a regio- and chemoselective hydropalladation step, followed by a photoinduced radical alkyl Heck reaction. This methodology represents a new reactivity mode for strained molecules and opens new avenues for photoinduced palladium catalysis. The reaction is compatible with a wide range of functional groups and can be applied to complex structures, delivering a diverse array of highly valuable and modifiable alkenylated cyclobutanes and cyclopropanes. A hydroalkenylation/diastereoselective rearrangement cascade toward a cyclopentene scaffold has also been demonstrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.