ArticlePLoS computational biology2022
Controlling microbial co-culture based on substrate pulsing can lead to stability through differential fitness advantages.
Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Beyond monoculture limits: a critical review of yeast co-cultures for xylitol production from lignocellulosic biomass : Yeast co-cultures for xylitol production.World journal of microbiology & biotechnology · 2026Review
- Application of a native Weissella starter to modulate the microbiome, metabolome, and quality characteristics of fermented Ma bamboo shoots.World journal of microbiology & biotechnology · 2026Article
- Growth control as a central regulator for tuning the cellular context.Journal of biological engineering · 2026Article
- Burden-aware feedback control of microbial consortia.Nature communications · 2026Article
- Simulation-based inference captures non-Markovian effects as exemplified in protein production kinetics through cell division.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Overriding Bioprocess Perturbations With a Cell-Machine Interface for Reliable Microbial Stress-Response Control.Microbial biotechnology · 2026Article
- Avoiding subtraction and division of stochastic signals using normalizing flows: NFdeconvolve.iScience · 2025Article
- Application of process analytical technology for real-time monitoring of synthetic co-culture bioprocesses.Analytical and bioanalytical chemistry · 2025Review
- Article
- COmmunity and Single Microbe Optimisation System (COSMOS).NPJ systems biology and applications · 2025Article
- Recent advances in yeast and bacteria co-cultivation for bioprocess applications.World journal of microbiology & biotechnology · 2025Review
- Directing microbial co-culture composition using cybernetic control.Cell reports methods · 2025Article
- The repertoire and levels of secondary metabolites in microbial cocultures depend on the inoculation ratio: a case study involving Aspergillus terreus and Streptomyces rimosus.Biotechnology letters · 2024Article
- Fitness cost associated with cell phenotypic switching drives population diversification dynamics and controllability.Nature communications · 2023Article
- Beyond Penicillin: The Potential of Filamentous Fungi for Drug Discovery in the Age of Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2023Review
- Article
- Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback.Nature communications · 2022Article
- Cybergenetic control of microbial community composition.Frontiers in bioengineering and biotechnology · 2022Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial consortia are an exciting alternative for increasing the performances of bioprocesses for the production of complex metabolic products. However, the functional properties of microbial communities remain challenging to control, considering the complex interaction mechanisms occurring between co-cultured microbial species. Indeed, microbial communities are highly dynamic and can adapt to changing environmental conditions through complex mechanisms, such as phenotypic diversification. We focused on stabilizing a co-culture of Saccharomyces cerevisiae and Escherichia coli in continuous cultures. Our preliminary data pointed out that transient diauxic shifts could lead to stable co-culture by providing periodic fitness advantages to the yeast. Based on a computational toolbox called MONCKS (for MONod-type Co-culture Kinetic Simulation), we were able to predict the dynamics of diauxic shift for both species based on a cybernetic approach. This toolbox was further used to predict the frequency of diauxic shift to be applied to reach co-culture stability. These simulations were successfully reproduced experimentally in continuous bioreactors with glucose pulsing. Finally, based on a bet-hedging reporter, we observed that the yeast population exhibited an increased phenotypic diversification process in co-culture compared with mono-culture, suggesting that this mechanism could be the basis of the metabolic fitness of the yeast.
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