Evidence map›Paper›PMID 36315500›Full record

ArticleJournal of proteome research2023

A Python Package for the Localization of Protein Modifications in Mass Spectrometry Data.

Anthony S Barente, Judit Villén

Abstract read
In one paragraph

Article in Journal of proteome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. TheJournal of proteome research · 2026
    Article
  3. Review
  4. Article
  5. The regulatory landscape of the yeast phosphoproteome.Nature structural & molecular biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anthony S BarenteDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0002-8641-3775
Judit VillénDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0002-1005-1739

Funding

Emergent properties of signaling network degradation that mediate homeostatic failure during agingR01AG056359 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT, VILLEN, JUDIT · 2017 to 2021
$2.9M
Towards a comprehensive roadmap of cellular signaling.R35GM119536 · NIGMS · UNIVERSITY OF WASHINGTON · PI VILLEN, JUDIT · 2016 to 2020
$2.2M
University of Washington PhD Training in Big Data for Genomics and NeuroscienceT32LM012419 · NLM · UNIVERSITY OF WASHINGTON · PI DANIEL, THOMAS L., FAIRHALL, ADRIENNE L · 2016 to 2019
$1.1M
NIA NIH HHS R01 AG056359NIGMS NIH HHS R35 GM119536NLM NIH HHS T32 LM012419
6 · The paper itself

Abstract

Determining the correct localization of post-translational modifications (PTMs) on peptides aids in interpreting their effect on protein function. While most algorithms for this task are available as standalone applications or incorporated into software suites, improving their versatility through access from popular scripting languages facilitates experimentation and incorporation into novel workflows. Here we describe pyAscore, an efficient and versatile implementation of the Ascore algorithm in Python for scoring the localization of user defined PTMs in data dependent mass spectrometry. pyAscore can be used from the command line or imported into Python scripts and accepts standard file formats from popular software tools used in bottom-up proteomics. Access to internal objects for scoring and working with modified peptides adds to the toolbox for working with PTMs in Python. pyAscore is available as an open source package for Python 3.6+ on all major operating systems and can be found at pyascore.readthedocs.io.

Indexed as

AlgorithmsSoftwareMass SpectrometryPeptidesProtein Processing, Post-TranslationalPeptidescomputationphosphorylationpost-translational modificationPythonsite localizationsoftware

Identifiers

PMID36315500
PMCPMC9898206

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.