Evidence map›Paper›PMID 36315275›Full record

ArticlePediatric nephrology (Berlin, Germany)2023

Predictors of successful discontinuation of continuous kidney replacement therapy in a pediatric cohort.

Elizabeth Y Wei, Kim T Vuong, Euyhyun Lee, Lin Liu, Elizabeth Ingulli, Nicole G Coufal

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026
    Review
  2. Article
  3. Kidney Support Therapy: Recent Advances.Indian journal of pediatrics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elizabeth Y WeiDepartment of Pediatrics, Division of Critical Care, University of California San Diego, 3020 Children's Way, MC 5065, San Diego, CA, 92123, USA. elizabethweimd@gmail.com.ORCID http://orcid.org/0000-0001-6233-5066
Kim T VuongRady Children's Hospital, San Diego, CA, USA.
Euyhyun LeeAltman Clinical and Translational Research Institute, University of California San Diego, San Diego, CA, USA.
Lin LiuAltman Clinical and Translational Research Institute, University of California San Diego, San Diego, CA, USA.
Elizabeth IngulliRady Children's Hospital, San Diego, CA, USA.
Nicole G CoufalDepartment of Pediatrics, Division of Critical Care, University of California San Diego, 3020 Children's Way, MC 5065, San Diego, CA, 92123, USA.
University of California San Diego · USUniversity of San Diego · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
NCATS NIH HHS UL1 TR001442
6 · The paper itself

Abstract

backgroundRecognizing the optimal time to discontinue continuous kidney replacement therapy (CKRT) is necessary to advance patient recovery and mitigate complications. The aim of this study was to identify predictors of successful CKRT cessation in pediatric patients.

methodsAll patients requiring CKRT between January 2010 and March 2021 were evaluated. Patients on peritoneal or hemodialysis, who transferred between institutions, or who did not trial off CKRT were excluded. Successful discontinuation was defined as remaining off CKRT for at least 7 days. Demographics, admission diagnoses, PRISM III scores, and reasons for CKRT initiation were obtained. Clinical and biochemical variables were evaluated at CKRT initiation and discontinuation and in the 12-h period following discontinuation. Comparisons were conducted using Wilcoxon rank sum and Fisher's exact tests for continuous and categorical variables, respectively. A logistic regression model was fitted to identify significant factors.

resultsNinety-nine patients underwent a trial off CKRT. Admission and initiation characteristics of the success and failure groups were similar. Patients who required re-initiation (n = 26) had longer ICU lengths of stay (27.2 vs. 44.5 days, p = 0.046) and higher in-hospital mortality (15.1% vs. 46.2%, p = 0.002). Urine output greater than 0.5 mL/kg/h irrespective of diuretic administration in the 6-h period before CKRT discontinuation was a significant predictor (AUC 0.72, 95% CI 0.60-0.84, p = 0.0009).

conclusionsDetermining the predictors of sustained CKRT discontinuation is critical. Urine output greater than 0.5 mL/kg/h in this pediatric cohort predicted successful discontinuation. Future studies are needed to validate this threshold in disease- and age-specific cohorts and evaluate additional biomarkers of kidney injury. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Acute Kidney InjuryContinuous Renal Replacement TherapyBiomarkersChildHospital MortalityHumansKidneyRenal Replacement TherapyRetrospective StudiesBiomarkersAcute kidney injury–rehabilitationAcute kidney injury–therapyContinuous kidney replacement therapyExtracorporeal dialysisPediatric intensive care unitsTime factors

Identifiers

PMID36315275
PMCPMC10234862
OpenAlexW4307773731

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.