ArticlePlant physiology2023
The unique sweet potato NAC transcription factor IbNAC3 modulates combined salt and drought stresses.
Article in Plant physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 85 citations in OpenAlex.
- miR164c-CUC2 Module Modulates Salinity Stress Tolerance in Soybean by Regulating Abscisic Acid Signalling and Reactive Oxygen Species Scavenging Pathways.Plant, cell & environment · 2026Article
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- Integrated bioinformatics and transcriptomic analysis of sweetpotato MYB genes reveals IbMYB150's role in salt tolerance.Plant cell reports · 2026Article
- Ectopic expression of safflower NAC transcription factorGM crops & food · 2025Article
- Alfalfa Transcription Factor MsNAC2a Orchestrates the Homeostasis of Salt Stress Responses via Reactive Oxygen Species Accumulation and Hydrogen Sulphide Depletion.Plant biotechnology journal · 2025Article
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- Identification of NAC Transcription Factors Associated with Leaf Senescence inInternational journal of molecular sciences · 2025Article
- Integrated Transcriptomic and Metabolomic Analyses Reveal Key Antioxidant Mechanisms inPlants (Basel, Switzerland) · 2025Article
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- Mutation ofPlants (Basel, Switzerland) · 2025Article
- Transcriptome‑wide excavation and expression pattern analysis of the NAC transcription factors in methyl jasmonate- and sodium chloride-induced Glycyrrhiza uralensis.Scientific reports · 2025Article
- Genome-wide identification ofFrontiers in genetics · 2025Article
- Growing vegetables in a warming world - a review of crop response to drought stress, and strategies to mitigate adverse effects in vegetable production.Frontiers in plant science · 2025Review
- MdSINA2-MdNAC104 Module Regulates Apple Alkaline Resistance by Affecting γ-Aminobutyric Acid Synthesis and Transport.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Overexpression ofGenes · 2024Article
- Article
- Transcriptional Control of Seed Life: New Insights into the Role of the NAC Family.International journal of molecular sciences · 2024Review
- Surviving a Double-Edged Sword: Response of Horticultural Crops to Multiple Abiotic Stressors.International journal of molecular sciences · 2024Review
- Pumpkin CmoDREB2A enhances salt tolerance of grafted cucumber through interaction with CmoNAC1 to regulate HHorticulture research · 2024Article
- A Comprehensive Analysis of the Peanut SQUAMOSA Promoter Binding Protein-like Gene Family and HowPlants (Basel, Switzerland) · 2024Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants often simultaneously experience combined stresses rather than a single stress, causing more serious damage, but the underlying mechanisms remain unknown. Here, we identified the stress-induced IbNAC3 from sweet potato (Ipomoea batatas) as a nucleus-localized transcription activator. IbNAC3 contains a unique activation domain whose MKD sequence confers transactivation activities to multiple other TFs and is essential for the activated expression of downstream target genes. Ectopic expression of IbNAC3 conferred tolerance to single and combined salt and drought stresses in Arabidopsis (Arabidopsis thaliana), and a group of NAM, ATAF1/2, and CUC2 (NAC) TFs, including ANAC011, ANAC072, ANAC083, ANAC100, and NAP, interacted with IbNAC3, and the specific domains responsible for each interaction varied. Intriguingly, IbNAC3 repressed the interaction among the five NACs, and knockout or mutation of ANAC011 and ANAC072 dramatically impaired combined stress tolerance. IbNAC3-ANAC072 and IbNAC3-NAP modules synergistically activated the MICROTUBULE-RELATED E3 LIGASE57 (MREL57) gene. Consistently, mutation of MREL57 and overexpression of WAVE-DAM-PENED2-LIKE7, encoding a target protein of MREL57, both remarkably impaired combined stress tolerance. Moreover, transgenic plants displayed abscisic acid (ABA) hyposensitivity by directly promoting the transcription of ENHANCED RESPONSE TO ABA 1, a key negative regulator of ABA signaling. The data unravel the unique IbNAC3 TF functions as a pivotal component in combined stress tolerance by integrating multiple regulatory events and ubiquitin pathways, which is essential for developing high-tolerant plants in natural environments.
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