Evidence map›Paper›PMID 36315000›Full record

ArticleJournal of magnetic resonance imaging : JMRI2023

Quantification of Prostate Cancer Metabolism Using 3D Multiecho bSSFP and Hyperpolarized [1-

Rafat Chowdhury, Christoph A Mueller, Lorna Smith, Fiona Gong, Marianthi-Vasiliki Papoutsaki, Harriet Rogers, Tom Syer, Saurabh Singh, Giorgio Brembilla, Adam Retter and 14 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Potential Clinical Applications of HyperpolarizedRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  4. Preclinical Applications of Magnetic Resonance Imaging in Oncology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  5. Article
  6. Article
  7. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  8. Theranostics · 2025
    Article
  9. A pharmacokinetic model for hyperpolarizedMagnetic resonance in medicine · 2024
    Article
  10. A vendor-neutral EPI sequence for hyperpolarizedMagnetic resonance in medicine · 2024
    Article
  11. Article
  12. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  13. Hyperpolarized Carbon-13 MRI in Breast Cancer.Diagnostics (Basel, Switzerland) · 2023
    Review
  14. Journal of the American Chemical Society · 2023
    Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 2 countries.

Rafat ChowdhuryCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Christoph A MuellerDepartment of Radiology, Medical Physics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-8187-9170
Lorna SmithCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Fiona GongCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Marianthi-Vasiliki PapoutsakiCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Harriet RogersCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Tom SyerCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Saurabh SinghCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Giorgio BrembillaCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Adam RetterCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Max BullockCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Lucy CaseltonCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Manju MathewCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Eoin DineenDivision of Surgery and Interventional Science, University College London, London, UK.
Thomas ParryCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Jürgen HennigDepartment of Radiology, Medical Physics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Dominik von ElverfeldtDepartment of Radiology, Medical Physics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Andreas B SchmidtDepartment of Radiology, Medical Physics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jan-Bernd HövenerDepartment of Radiology, and Neuroradiology, Section Biomedical Imaging, MOIN CC, University Medical Center Schleswig-Holstein, University of Kiel, Kiel, Germany.
Mark EmbertonDivision of Surgery and Interventional Science, University College London, London, UK.
David AtkinsonCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Alan BainbridgeDepartment of Medical Physics and Biomedical Engineering, University College London Hospitals NHS Foundation Trust, London, UK.
David G GadianCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
Shonit PunwaniCentre for Medical Imaging, Division of Medicine, University College London, London, UK.ORCID 0000-0002-1014-0870
University College London · GBUniversity of Freiburg · DEUniversity College London Hospitals NHS Foundation Trust · GBGreat Ormond Street Hospital · GBUniversity Hospital Schleswig-Holstein · DE

Funding

Biotechnology and Biological Sciences Research Council BB/R505973/1Cancer Research UK 26854Cancer Research UK C42780/A26854Department of HealthMedical Research Council MR/M009092/1
6 · The paper itself

Abstract

backgroundThree-dimensional (3D) multiecho balanced steady-state free precession (ME-bSSFP) has previously been demonstrated in preclinical hyperpolarized (HP) PURPOSE: To validate a signal simulation framework for the use of sequence parameter optimization. To demonstrate the feasibility of ME-bSSFP for HP STUDY TYPE: Retrospective single-center cohort study. PHANTOMS/POPULATION: Phantoms containing aqueous solutions of [1- ASSESSMENT: The primary endpoint was the analysis of pyruvate-to-lactate conversion in PCa and healthy prostate regions of interest (ROIs) using model-free area under the curve (AUC) ratios and a one-directional kinetic model (k STATISTICAL TESTS: Pearson correlation coefficients with 95% confidence intervals and paired t-tests. The level of statistical significance was set at P < 0.05.

resultsStrong correlations between simulated and empirical ME-bSSFP signals were found (r > 0.96). Therefore, the simulation framework was used for sequence optimization. Whole prostate metabolic HP DATA

conclusionMetabolic HP EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 1.

Indexed as

Prostatic NeoplasmsPyruvic AcidAgedCohort StudiesHumansLactic AcidMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesLactic AcidPyruvic AcidbSSFPhyperpolarized [1-13C] pyruvatemetabolic 13C-MRI

Identifiers

PMID36315000
PMCPMC10946772
OpenAlexW4307773591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.