Evidence map›Paper›PMID 36314966›Full record

ArticleMicrobiology spectrum2022

Impact of Protein Nitration on Influenza Virus Infectivity and Immunogenicity.

Harrison Dulin, Nathan Hendricks, Duo Xu, Linfeng Gao, Keidy Wuang, Huiwang Ai, Rong Hai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Harrison DulinCell, Molecular, and Developmental Biology Graduate Program, University of California, Riversidegrid.266097.c, Riverside, California, USA.
Nathan HendricksProteomics Core, University of California, Riversidegrid.266097.c, Riverside, California, USA.
Duo XuMicrobiology and Plant Pathology, University of California, Riversidegrid.266097.c, Riverside, California, USA.
Linfeng GaoMicrobiology and Plant Pathology, University of California, Riversidegrid.266097.c, Riverside, California, USA.
Keidy WuangMicrobiology and Plant Pathology, University of California, Riversidegrid.266097.c, Riverside, California, USA.
Huiwang AiDepartment of Molecular Physiology and Biological Physics, University of Virginiagrid.27755.32, Charlottesville, Virginia, USA.
Rong HaiCell, Molecular, and Developmental Biology Graduate Program, University of California, Riversidegrid.266097.c, Riverside, California, USA.ORCID 0000-0002-0577-4676
University of California, Riverside · USUniversity of Virginia · US

Funding

Red and Far-Red Fluorescent Biosensors for Compartmentalized Redox SignalingR01GM129291 · NIGMS · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2018 to 2021
$2.1M
Mechanistic Insights into flavivirus NS5-mediated STAT2 SuppressionR01AI153419 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HAI, RONG · 2021 to 2025
$1.9M
Mechanistic understanding and inhibition of Zika NS5 proteinR21AI147057 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HAI, RONG, SONG, JIKUI · 2019 to 2020
$739k
An LTQ-Orbitrap Elite with ETD for the Keck Proteomics FacilityS10OD010669 · OD · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WANG, YINSHENG · 2013 to 2013
$600k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 1R21AI147057HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM129291NIAID NIH HHS R01 AI153419NIAID NIH HHS R21 AI147057NIGMS NIH HHS R01 GM129291NIH HHS S10 OD010669
6 · The paper itself

Abstract

Influenza viruses are deadly respiratory pathogens of special importance due to their long history of global pandemics. During influenza virus infections, the host responds by producing interferons, which activate interferon-stimulated genes (ISGs) inside target cells. One of these ISGs is inducible nitric oxide synthase (iNOS). iNOS produces nitric oxide (NO) from arginine and molecular oxygen inside the cell. NO can react with superoxide radicals to form reactive nitrogen species, principally peroxynitrite. While much work has been done studying the many roles of nitric oxide in influenza virus infections, the direct effect of peroxynitrite on influenza virus proteins has not been determined. Manipulations of NO, either by knocking out iNOS or chemically inhibiting NO, produced no change in virus titers in mouse models of influenza infection. However, peroxynitrite has a known antimicrobial effect on various bacteria and parasites, and the reason for its lack of antimicrobial effect on influenza virus titers

Indexed as

Anti-Infective AgentsCommunicable DiseasesInfluenza, HumanOrthomyxoviridaeVirus DiseasesAnimalsHemagglutininsHumansMiceNitric OxidePeroxynitrous AcidTyrosineAnti-Infective AgentsHemagglutininsNitric OxidePeroxynitrous AcidTyrosinehemagglutinininfectioninfluenzalung infectionnitric oxide synthasenitrotyrosineperoxynitrite

Identifiers

PMID36314966
PMCPMC9769652
OpenAlexW4307777301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.