Evidence map›Paper›PMID 36314942›Full record

ArticleAutophagy2023

Transient systemic autophagy ablation irreversibly inhibits lung tumor cell metabolism and promotes T-cell mediated tumor killing.

Kyle Nunn, Jessie Yanxiang Guo

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kyle NunnDivision of Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.ORCID 0000-0003-4397-6225
Jessie Yanxiang GuoDivision of Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Rutgers, The State University of New Jersey · US

Funding

Elucidate the mechanism of autophagy in supporting Lkb1-deficient lung tumorigenesis and metastasisR01CA237347 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI GUO, YANXIANG · 2020 to 2025
$1.8M
The role of autophagy in Kras-driven lung cancerK22CA190521 · NCI · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI GUO, YANXIANG · 2015 to 2017
$629k
Targeting autophagy to increase the sensitivity of LKB1-deficient lung tumors to angiogenesis inhibitorR21CA263136 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI GUO, YANXIANG · 2022 to 2023
$400k
NCI NIH HHS K22 CA190521NCI NIH HHS R01 CA237347NCI NIH HHS R21 CA263136
6 · The paper itself

Abstract

Macroautophagy/autophagy is a highly conserved catabolic process pivotal to cellular homeostasis and support of tumorigenesis. Being a potential therapeutic target for cancer, we have worked to understand the implications of autophagy inhibition both systemically, and tumor-specifically. We utilized inducible expression of

Indexed as

Lung NeoplasmsT-LymphocytesAnimalsAutophagyAutophagy-Related Protein 5CarcinogenesisCell Line, TumorCell Transformation, NeoplasticMiceAutophagy-Related Protein 5Autophagycancer metabolismcancer therapyimmune evasionKRASlung tumor

Identifiers

PMID36314942
PMCPMC10262792
OpenAlexW4307892344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.