ArticleMicrobiology spectrum2022
Comparative Genomics of Listeria monocytogenes Isolates from Ruminant Listeriosis Cases in the Midwest United States.
Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Epidemiology, clinical and pathological features and outcomes of listeriosis in ruminants: a systematic review and meta-analysis.The veterinary quarterly · 2025Pooled it
- Biofilm forming capacity, sanitizer tolerance, and genetic characterization of persistent and non-persistentBiofilm · 2026Article
- High-quality draft genome of the Listeria monocytogenes, one more vaccine strain against livestock listeriosis.Scientific data · 2026Article
- Genomic characterization of Listeria monocytogenes isolated from small ruminants in integrated crop-livestock systems.BMC microbiology · 2026Article
- Listeriosis: Characteristics, Occurrence in Domestic Animals, Public Health Significance, Surveillance and Control.Microorganisms · 2024Review
- Antimicrobial Effects of Plant-Based Supplements on Gut Microbial Diversity in Small Ruminants.Pathogens (Basel, Switzerland) · 2023Review
- Genomic and pathogenicity islands ofFrontiers in molecular biosciences · 2023Review
- Genome-Wide Association Study ofMicroorganisms · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ruminants are a well-known reservoir for Listeria monocytogenes. In addition to asymptomatic carriage of the pathogen, ruminants can also acquire listeriosis and develop clinical manifestations in the form of neurologic or fetal infections, similar to those occurring in humans. Genomic characterization of ruminant listeriosis cases in Europe have identified lineage 1 and 2 strains associated with infection, as well as clonal complexes (CCs) that are commonly isolated from human cases of listeriosis; however, there is little information on the diversity of L. monocytogenes from ruminant listeriosis in the United States. In this study, we characterized and compared 73 L. monocytogenes isolates from ruminant listeriosis cases from the Midwest and the Upper Great Plains collected from 2015 to 2020. Using whole-genome sequence data, we classified the isolates and identified key virulence factors, stress-associated genes, and mobile genetic elements within our data set. Our isolates belonged to three different lineages: 31% to lineage 1, 53% to lineage 2, and 15% to lineage 3. Lineage 1 and 3 isolates were associated with neurologic infections, while lineage 2 showed a greater frequency of fetal infections. Additionally, the presence of mobile elements, virulence-associated genes, and stress and antimicrobial resistance genes was evaluated. These genetic elements are responsible for most of the subgroup-specific features and may play a key role in the spread of hypervirulent clones, including the spread of hypervirulent CC1 clone commonly associated with disease in humans, and may explain the increased frequency of certain clones in the area.
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