Evidence map›Paper›PMID 36314925›Full record

ArticleMicrobiology spectrum2022

Development and Validation of a Protein Array for Detection of Antibodies against the Tick-Borne Pathogen Borrelia miyamotoi.

Dieuwertje Hoornstra, Olga A Stukolova, Ludmila S Karan, Denis S Sarksyan, Nadezhda M Kolyasnikova, Mikhail L Markelov, Anna S Cherkashina, Anna S Dolgova, Anna E Sudina, Marina I Sokolova and 2 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Tropical medicine and infectious disease · 2026
    Article
  3. Article
  4. Observational
  5. HumanPathogens (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Dieuwertje Hoornstra *Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.ORCID 0000-0003-0347-2049
Olga A Stukolova *Central Research Institute of Epidemiology, Moscow, Russia.ORCID 0000-0002-0741-3735
Ludmila S KaranCentral Research Institute of Epidemiology, Moscow, Russia.
Denis S SarksyanIzhevsk State Medical Academygrid.445102.6, Izhevsk, Russia.ORCID 0000-0001-6263-6627
Nadezhda M KolyasnikovaCentral Research Institute of Epidemiology, Moscow, Russia.ORCID 0000-0002-9934-2582
Mikhail L MarkelovIzmerov Research Institute of Occupational Health, Moscow, Russia.
Anna S CherkashinaCentral Research Institute of Epidemiology, Moscow, Russia.ORCID 0000-0001-7970-7495
Anna S DolgovaSt. Petersburg Pasteur Institute of Epidemiology and Microbiology, Saint Petersburg, Russia.ORCID 0000-0001-8730-4872
Anna E SudinaCentral Research Institute of Epidemiology, Moscow, Russia.
Marina I SokolovaCentral Research Institute of Epidemiology, Moscow, Russia.
Alexander E Platonov *Central Research Institute of Epidemiology, Moscow, Russia.ORCID 0000-0001-7450-0081
Joppe W Hovius *Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.
Central Research Institute of Epidemiology · RUAmsterdam UMC Location University of Amsterdam · NLIzhevsk State Medical Academy · RURussian Academy of Sciences · RUSaint Petersburg Pasteur Institute · RUThe Federal State Budgetary Scientific Institution "Izmerov Research Institute of Occupational Health" · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current serological tests for the emerging tick-borne pathogen Borrelia miyamotoi lack diagnostic accuracy. To improve serodiagnosis, we investigated a protein array simultaneously screening for IgM and IgG reactivity against multiple recombinant B. miyamotoi antigens. The array included six B. miyamotoi antigens: glycerophosphodiester phosphodiesterase (GlpQ), multiple variable major proteins (Vmps), and flagellin. Sera included samples from cases of PCR-proven Borrelia miyamotoi disease (BMD), multiple potentially cross-reactive control groups (including patients with culture-proven Lyme borreliosis, confirmed Epstein-Barr virus, cytomegalovirus, or other spirochetal infections), and several healthy control groups from regions where

Indexed as

Antibodies, BacterialBorreliaBorrelia InfectionsIxodesAnimalsFlagellinHumansImmunoglobulin GImmunoglobulin MProtein Array AnalysisAntibodies, BacterialFlagellinImmunoglobulin GImmunoglobulin MBorrelia miyamotoiBorrelia miyamotoi diseasehard-tick-borne relapsing feverrelapsing fever Borreliaserology

Identifiers

PMID36314925
PMCPMC9769530
OpenAlexW4307779121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.