Evidence map›Paper›PMID 36314787›Full record

ArticleAntimicrobial agents and chemotherapy2022

Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library.

Arif Nurkanto, Riyo Imamura, Yulia Rahmawati, Erwahyuni Endang Prabandari, Danang Waluyo, Takeshi Annoura, Kazuki Yamamoto, Masakazu Sekijima, Yuki Nishimura, Takayoshi Okabe and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. In Silico Screening ofBiologics : targets & therapy · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Arif NurkantoResearch Center for Biosystematics and Evolution, Research Organization for Life Sciences and Environmental, National Research and Innovation Agency (BRIN), Cibinong, Indonesia.ORCID 0000-0003-2449-7122
Riyo ImamuraDrug Discovery Initiative (DDI), The University of Tokyo, Tokyo, Japan.
Yulia RahmawatiGraduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Erwahyuni Endang PrabandariResearch Center for Vaccine and Drug, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, Indonesia.
Danang WaluyoResearch Center for Vaccine and Drug, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, Indonesia.
Takeshi AnnouraDepartment of Parasitology, National Institute of Infectious Diseases (NIID), Tokyo, Japan.
Kazuki YamamotoDepartment of Computer Science, Tokyo Institute of Technology, Tokyo, Japan.
Masakazu SekijimaDepartment of Computer Science, Tokyo Institute of Technology, Tokyo, Japan.
Yuki NishimuraDepartment of Biological Sciences, Graduate of School of Sciences, The University of Tokyo, Chiba, Japan.
Takayoshi OkabeDrug Discovery Initiative (DDI), The University of Tokyo, Tokyo, Japan.
Tomoo ShibaDepartment of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, Japan.
Norio ShibataDepartment of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Nagoya, Japan.
Hirotatsu KojimaDrug Discovery Initiative (DDI), The University of Tokyo, Tokyo, Japan.
James DuffyMedicines for Malaria Venture, International Center Cointrin, Geneva, Switzerland.
Tomoyoshi NozakiGraduate School of Medicine, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPNational Research and Innovation Agency · IDTokyo Institute of Technology · JPKyoto Institute of Technology · JPMedicines for Malaria Venture · CHNagoya Institute of Technology · JPNational Institute of Infectious Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria is a mosquito-borne fatal infectious disease that affects humans and is caused by

Indexed as

AntimalarialsCoenzyme APlasmodium falciparumAnimalsHep G2 CellsHigh-Throughput Screening AssaysHumansLife Cycle StagesMalaria, FalciparumPhosphotransferases (Alcohol Group Acceptor)Small Molecule LibrariesAntimalarialsCoenzyme Adephospho-CoA kinasePhosphotransferases (Alcohol Group Acceptor)Small Molecule Librariesantimalarial agentscoenzyme Adephospho-CoA kinasehigh-throughput screeninginhibitormalariaPlasmodium falciparum

Identifiers

PMID36314787
PMCPMC9664868
OpenAlexW4307778491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.