ArticleJournal of the Pediatric Infectious Diseases Society2022
Pediatric Tuberculosis Diagnostics: Present and Future.
Article in Journal of the Pediatric Infectious Diseases Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Cepheid 9-gene host mRNA expression across the spectrum of Mycobacterium tuberculosis infection and disease: insights across the lifespan.EBioMedicine · 2026Article
- Under-reporting of Childhood Tuberculosis Cases in Indonesia and Associated Factors.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Article
- Diagnostic Yield of Tongue Swab- Compared to Sputum-Based Molecular Testing for Tuberculosis in Four High-Burden Countries.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Barriers to treatment completion among drug-sensitive tuberculosis patients: evidence from Indonesia's tuberculosis surveillance system.Osong public health and research perspectives · 2026Article
- Challenges encountered in managing tuberculosis in children: a case report.Journal of medical case reports · 2026Article
- From gaps to progress: five-year global advances in the diagnosis of pediatric tuberculosis.Frontiers in pediatrics · 2026Review
- Plasma kynurenine/tryptophan ratio as a sensitive blood-based diagnostic tool for tuberculosis: a diagnostic accuracy study among children living with HIV.Frontiers in microbiology · 2026Article
- Article
- Factors contributing to low tuberculosis diagnosis among children aged 0-14 years in Gem Sub County in Siaya County, Kenya.PloS one · 2026Article
- Exploring non-sputum biosignatures for tuberculosis triage and diagnosis in children living with HIV.Expert review of molecular diagnostics · 2025Review
- Recent Advances in Pediatric Infectious Diseases: A Review of Diagnostic and Therapeutic Strategies.Cureus · 2025Review
- Electro-impedimetric detection of human anti-mycolate antibody biomarkers of TB before, during, and after treatment.Biomarkers in medicine · 2025Observational
- Semantic Segmentation of TB in Chest X-rays: a New Dataset and Generalization Evaluation.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Age- and sex-specific care cascades to detect gaps in the care of children with tuberculosis in Bangladesh: a cohort study.Journal of global health · 2025Article
- A Comprehensive Review of the Diagnostics for Pediatric Tuberculosis Based on Assay Time, Ease of Operation, and Performance.Microorganisms · 2025Review
- Diagnostic performance of chest radiography for pediatric tuberculosis across high- and low-burden settings.Frontiers in pediatrics · 2025Article
- Applications and prospects of artificial intelligence in the auxiliary diagnosis of pediatric pulmonary tuberculosis.Frontiers in microbiology · 2025Review
- Assessment of radiological capacity and disparities in TB diagnosis: a comparative study of Mozambique, South Africa and Spain.BMJ public health · 2024Article
- Prevalence and Associated Factors of Children Tuberculosis in Southeast Asia Countries: A Systematic Review.The Malaysian journal of medical sciences : MJMS · 2024Review
- Social and health factors associated with unfavourable treatment outcomes in children and adolescents with drug-sensitive tuberculosis in Brazil: a national retrospective cohort study.Lancet regional health. Americas · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The current diagnostic abilities for the detection of pediatric tuberculosis are suboptimal. Multiple factors contribute to the under-diagnosis of intrathoracic tuberculosis in children, namely the absence of pathognomonic features of the disease, low bacillary loads in respiratory specimens, challenges in sample collection, and inadequate access to diagnostic tools in high-burden settings. Nonetheless, the 2020s have witnessed encouraging progress in the area of novel diagnostics. Recent WHO-endorsed rapid molecular assays hold promise for use in service decentralization strategies, and new policy recommendations include stools as an alternative, child-friendly specimen for testing with the GeneXpert assay. The pipeline of promising assays in mid/late-stage development is expanding, and novel pediatric candidate biomarkers based on the host immune response are being identified for use in diagnostic and triage tests. For a new test to meet the pediatric target product profiles prioritized by the WHO, it is key that the peculiarities and needs of the hard-to-reach pediatric population are considered in the early planning phases of discovery, validation, and implementation studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.