Evidence map›Paper›PMID 36314485›Full record

ArticleEuropean journal of neurology2023

Comparative features and outcomes of major neurological complications of COVID-19.

Ettore Beghi, Elena Moro, Eugenia Irene Davidescu, Bogdan Ovidiu Popescu, Oxana Grosu, Franco Valzania, Maria Sofia Cotelli, Gordana Kiteva-Trenchevska, Maria Zakharova, Tibor Kovács and 20 more

Abstract read
In one paragraph

Article in European journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Blood neurofilament light chain and S100B as biomarkers of neurological involvement and functional prognosis in COVID-19: a multicenter study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Observational
  4. Article
  5. Article
  6. European Academy of Neurology: First 10 years.European journal of neurology · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Ettore BeghiIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.ORCID 0000-0003-2542-0469
Elena MoroCentre Hospitalier Universitaire de Grenoble, Service de Neurologie, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.ORCID 0000-0002-7968-5908
Eugenia Irene DavidescuNeurology Department, Colentina Clinical Hospital, Bucharest, Romania and Department of Clinical Neurosciences, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.ORCID 0000-0001-6862-5515
Bogdan Ovidiu PopescuNeurology Department, Colentina Clinical Hospital, Bucharest, Romania and Department of Clinical Neurosciences, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Oxana GrosuDiomid Gherman Institute of Neurology and Neurosurgery, Chișinău, Moldova.
Franco ValzaniaNeurology Unit, Neuromotor and Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Maria Sofia CotelliNeurology Unit ASST Valcamonica, Brescia, Italy.
Gordana Kiteva-TrenchevskaUniversity Clinic for Neurology, Medical Faculty, University "Ss. Cyril and Methodius", Skopje, Macedonia.
Maria ZakharovaDepartment of the Research Centre of Neurology, Moscow, Russia.
Tibor KovácsSemmelweis University Budapest, Budapest, Hungary.ORCID 0000-0002-8603-8848
Carmel ArmonTel Aviv University School of Medicine and Shamir (Assaf Harofeh) Medical Center, Tel Aviv, Israel.
Waldemar BrolaDepartment of Neurology, Specialist Hospital Konskie, Collegium Medicum, Jan Kochanowski University, Kielce, Poland.
Clarissa Lin YasudaCEPID BRAINN - Brazilian Institute of Neuroscience and Neurotechnology and University of Campinas, Campinas, Brazil.
Luís F MaiaNeurology Department Hospital Santo António - CHUP, Porto, Portugal.
Arijana Lovrencic-HuzjanDepartment of Neurology, UHC Sestre milosrdnice, Zagreb, Croatia.
Mafalda Maria Laracho de SeabraDepartment of Neurology, Centro Hospitalar Universitário de São João, E.P.E, Porto, Spain.
Rafael Avalos-PavonNeurology Service, Facultad de Medicina, Universidad Autonoma de San Luis Potosi. Hospital Central, San Luis Potosi, Mexico.
Anne Hege AamodtDepartment of Neurology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-2824-2760
Sara MeoniCentre Hospitalier Universitaire de Grenoble, Service de Neurologie, Grenoble Institute of Neurosciences, Grenoble Alpes University, Grenoble, France.
Victoria GrybDepartment of Neurology and Neurosurgery, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine.
Serefnur OzturkSelcuk University Faculty of Medicine, Department of Neurology, Konya, Turkey.
Omer KaradasUniversity of Health Science, Gulhane School of Medicine, Neurology Department, Ankara, Turkey.
Ingomar KrehanDepartment of Neurology, Kepler University Hospital, Linz, Austria.
Maurizio A LeoneIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Maria LolichEuropean Acadmey of Neurology, Vienna, Austria.
Elisa BianchiIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Verena RassNeurocritical Care Unit, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-4241-5891
Raimund HelbokNeurocritical Care Unit, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-5682-0145
Claudio L A BassettiDepartment of Neurology, University Hospital of Bern, Bern, Switzerland.ORCID 0000-0002-4535-0245
ENERGY Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe aim of this study was to assess the neurological complications of SARS-CoV-2 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations.

methodsThe data source was a registry established by the European Academy of Neurology during the first wave of the COVID-19 pandemic. Neurologists collected data on patients with COVID-19 seen as in- and outpatients and in emergency rooms in 23 European and seven non-European countries. Prospective and retrospective data included patient demographics, lifestyle habits, comorbidities, main COVID-19 complications, hospital and intensive care unit admissions, diagnostic tests, and outcome. Acute/subacute selected neurological manifestations in patients with COVID-19 were analysed, comparing individuals with and without each condition for several risk factors.

resultsBy July 31, 2021, 1523 patients (758 men, 756 women, and nine intersex/unknown, aged 16-101 years) were registered. Neurological manifestations were diagnosed in 1213 infected patients (79.6%). At study entry, 978 patients (64.2%) had one or more chronic general or neurological comorbidities. Predominant acute/subacute neurological manifestations were cognitive dysfunction (N = 449, 29.5%), stroke (N = 392, 25.7%), sleep-wake disturbances (N = 250, 16.4%), dysautonomia (N = 224, 14.7%), peripheral neuropathy (N = 145, 9.5%), movement disorders (N = 142, 9.3%), ataxia (N = 134, 8.8%), and seizures (N = 126, 8.3%). These manifestations tended to differ with regard to age, general and neurological comorbidities, infection severity and non-neurological manifestations, extent of association with other acute/subacute neurological manifestations, and outcome.

conclusionsPatients with COVID-19 and neurological manifestations present with distinct phenotypes. Differences in age, general and neurological comorbidities, and infection severity characterize the various neurological manifestations of COVID-19.

Indexed as

COVID-19Nervous System DiseasesFemaleHumansPandemicsProspective StudiesRetrospective StudiesSARS-CoV-2SeizurescoronavirusCOVID-19neurological complicationsneurology

Identifiers

PMID36314485
PMCPMC9874573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.