Evidence map›Paper›PMID 36314372›Full record

Trial reportJournal of clinical apheresis2023

Therapeutic plasma exchange in patients with sepsis: Secondary analysis of a cluster-randomized controlled trial.

Xiang Luo, Xiaoling Li, Xiaoyan Lai, Lu Ke, Jing Zhou, Man Liu, Longxiang Cao, Lingyan Fu, Chinese Critical Care Nutrition Trials Group (CCCNTG)

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical apheresis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Observational
  4. Impact of extracorporeal circuits on systemic drug levels - a scoping review.Journal of anesthesia, analgesia and critical care · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xiang LuoDepartment of Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.
Xiaoling LiDepartment of Anesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.
Xiaoyan LaiDepartment of Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.
Lu KeNational Institute of Healthcare Data Science, Nanjing University, Nanjing, China.
Jing ZhouDepartment of Critical Care Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, China.
Man LiuNational Institute of Healthcare Data Science, Nanjing University, Nanjing, China.
Longxiang CaoDepartment of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Lingyan FuDepartment of Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.
Chinese Critical Care Nutrition Trials Group (CCCNTG)
Fujian Medical University · CNNanjing University · CNFirst Affiliated Hospital of Fujian Medical University · CNNanjing Medical University · CN

Funding

Longyan City Science and Technology Plan Project 2020LYF17026
6 · The paper itself

Abstract

introductionSepsis is life-threatening organ dysfunction caused by infection-related inflammatory response. Therapeutic plasma exchange (TPE) can remove inflammatory mediators and benefit patients in different disease settings. However, no solid evidence showed the efficacy and safety of TPE in sepsis.

methodsThis study was a secondary analysis of a randomized controlled trial. Critically ill patients with sepsis were divided into two groups according to whether treated with TPE. The primary outcome was the delta Sequential Organ Failure Assessment (SOFA) score from days 1 to 7. Secondary outcomes included new-onset organ failure, intensive care unit (ICU)-free and alive days to day 28, and 28-day mortality. Propensity score-matched (PSM) analysis was applied to control confounders. Analysis of covariance (ANCOVA) and logistic regression were used to assess the association between TPE and selected outcomes.

resultsAmong the 2772 critically ill patients enrolled in the trial, 742 patients with sepsis were selected and 22 patients received TPE were matched with 22 control patients. No significant difference was found in the delta SOFA score and 28-day mortality between TPE group and control group. The ICU-free and alive days in the TPE group were significantly shorter than the control group.

conclusionsTPE may be not associated with improvement of organ failure and mortality in critically ill patients with sepsis and may be associated with a prolonged ICU stay.

Indexed as

Plasma ExchangeSepsisCritical IllnessHumansIntensive Care UnitsRetrospective Studiesintensive care unitpropensity score-matchedsepsisSequential Organ Failure Assessment scoretherapeutic plasma exchange

Identifiers

PMID36314372
PMCPMC10092885
OpenAlexW4307776008

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.